Glutamic acid--tyrosine (1/1) | 27498-47-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glutamic acid--tyrosine (1/1)
• 英文别名: 2-amino-3-(4-hydroxyphenyl)propanoic acid;2-aminopentanedioic acid
• CAS: 27498-47-1
• 化学式: C14H20N2O7
• 分子量: 328.32
• InChiKey: LZKJGAQEZMGEBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.39
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  184
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• CYANOQUINOLINE DERIVATIVES
  申请人：Zhang Hesheng

  公开号：US20130225579A1

  公开（公告）日：2013-08-29

  Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R 1 , R 2 , R 3 and R 4 are each as defined in the present application.

  公开了一种公式I的化合物，其立体异构体，其顺反异构体，其互变异构体，或它们的混合物，或其药物可接受的盐，其溶剂化物或其前药，其中R1，R2，R3和R4各自如在本申请中定义。
• Hapten-carrier conjugates and uses thereof
  申请人：Bachmann F. Martin

  公开号：US20050281845A1

  公开（公告）日：2005-12-22

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种包含半抗原与载体的共轭物的组合物，其具有有序和重复的排列方式，并提供了制备这种组合物的方法。本发明的共轭物和组合物可以包含各种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共轭物可用于诱导免疫反应，用于各种治疗、预防和诊断方案。在某些实施例中，使用本发明的共轭物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。
• Hapten-Carrier Conjugates and Uses Thereof
  申请人：BACHMANN Martin F.

  公开号：US20130142821A1

  公开（公告）日：2013-06-06

  The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

  本发明提供了一种由载体和半抗原共价结合的有序和重复阵列的组合物及其制备方法。该发明的共价结合物和组合物可以包含多种半抗原，包括激素、毒素和药物，特别是成瘾药物如尼古丁。本发明的组合物和共价结合物可用于诱导对半抗原的免疫反应，这对于各种治疗、预防和诊断方案都有用。在某些实施例中，使用本发明的共价结合物、组合物和方法产生的免疫反应可用于预防或治疗药物成瘾及与药物成瘾相关的疾病。
• Formulations of flibanserin
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2090297A1

  公开（公告）日：2009-08-19

  The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of Flibanserin, at least one pharmaceutically acceptable pH modifier and at least one pharmaceutically acceptable excipient achieving and maintaining supersaturation.

  本发明提供了药物释放系统，该系统包含治疗有效量的氟班色林、至少一种药学上可接受的 pH 值调节剂和至少一种药学上可接受的赋形剂，可实现并维持过饱和度。
• Angiotensin peptide-carrier conjugates and uses thereof
  申请人：Cytos Biotechnology AG

  公开号：EP2090319A2

  公开（公告）日：2009-08-19

  The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.

  本发明提供了哺乳动物肽类激素血管紧张素原、血管紧张素Ⅰ和血管紧张素Ⅱ的肽衍生物的共轭物，通过将肽衍生物与载体，特别是病毒样颗粒（VLP）偶联，以重复支架呈现。本发明还提供了生产这种共轭物的方法，以及所得免疫原共轭物在治疗和预防与肾素激活血管紧张素系统有关的疾病方面的免疫治疗用途。