t-丁基-L-天冬氨酰-L-脯氨酸 | 64642-65-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: t-丁基-L-天冬氨酰-L-脯氨酸
• 中文别名: FMOC-3-苯甲酰基赤藓糖苷
• 英文名称: (2S)-1-[(2S)-2-amino-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoyl]pyrrolidine-2-carboxylic acid
• CAS: 64642-65-5
• 化学式: C₁₃H₂₂N₂O₅
• 分子量: 286.32
• InChiKey: ZSUIRCJCXXBWHP-IUCAKERBSA-N

物化性质

• 熔点：
  96-105°C
• 沸点：
  496.7±45.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMF、水

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• WO2020094471A5
  申请人：——

  公开号：WO2020094471A5

  公开（公告）日：2022-08-17
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THE TREATMENT, PREVENTION, OR MANAGEMENT OF HYPERPROLIFERATIVE DISORDERS<br/>[FR] COMPOSÉS, COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES POUR LE TRAITEMENT, LA PRÉVENTION OU LA GESTION DE TROUBLES HYPERPROLIFÉRATIFS
  申请人：[en]VINCERX PHARMA GMBH

  公开号：WO2023057813A1

  公开（公告）日：2023-04-13

  Disclosed herein are compounds, pharmaceutical compositions, and methods for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals. Compounds disclosed herein are cytotoxic or cytostatic (e.g., 7-ethyl camptothecin) prodrugs, conjugated to an integrin binding moiety via cleavable linkers and/or functional spacers.
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THE TREATMENT, PREVENTION, OR MANAGEMENT OF HYPERPROLIFERATIVE DISORDERS<br/>[FR] COMPOSÉS, COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES DE TRAITEMENT, DE PRÉVENTION OU DE GESTION DE TROUBLES HYPERPROLIFÉRATIFS
  申请人：[en]VINCERX PHARMA GMBH

  公开号：WO2023057814A1

  公开（公告）日：2023-04-13

  Disclosed herein are compounds, pharmaceutical compositions, and methods for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals. Compounds disclosed herein are hexacyclic topoisomerase inhibitor prodrugs, conjugated to an integrin binding moiety via cleavable linkers and/or functional spacers.