1,1,3,3-tetrapropylisoindoline | 1234321-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1,1,3,3-tetrapropylisoindoline
• 英文别名: 1,1,3,3-tetrapropyl-2H-isoindole
• CAS: 1234321-52-8
• 化学式: C₂₀H₃₃N
• 分子量: 287.489
• InChiKey: WNGJCVHWVCNYHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1,3,3-tetrapropylisoindoline 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以96%的产率得到1,1,3,3-tetrapropylisoindolin-2-oxyl
  参考文献：
  名称：

  Ligand-Enhanced Aliphatic Carbon−Carbon Bond Activation of Nitroxides by Rhodium(II) Porphyrin

  摘要：

  Rh(tmp) underwent Ph3P-enhanced aliphatic carbon carbon bond activation with various nitroxides. (Ph3P)Rh(tmp), rapidly formed from Rh(tmp) and Ph3P, enhanced the rate, selectivity, and yield in comparison to Rh(tmp). From kinetic studies, the rate of reaction showed a first-order dependence on both Rh(tmp) and TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidine-1-oxyl) and saturation kinetics on Ph3P. The rate enhancement of (Ph3P)Rh(tmp) over Rh(tmp) was estimated to be about 11 at 70 degrees C.

  DOI：

  10.1021/om1000869
• 作为产物：
  描述：

  2-benzyl-1,1,3,3-tetrapropylisoindoline 在 palladium 10% on activated carbon 、 氢气 、 溶剂黄146 作用下， 20.0 ℃ 、413.69 kPa 条件下， 反应 72.0h， 以83%的产率得到1,1,3,3-tetrapropylisoindoline
  参考文献：
  名称：

  Ligand-Enhanced Aliphatic Carbon−Carbon Bond Activation of Nitroxides by Rhodium(II) Porphyrin

  摘要：

  Rh(tmp) underwent Ph3P-enhanced aliphatic carbon carbon bond activation with various nitroxides. (Ph3P)Rh(tmp), rapidly formed from Rh(tmp) and Ph3P, enhanced the rate, selectivity, and yield in comparison to Rh(tmp). From kinetic studies, the rate of reaction showed a first-order dependence on both Rh(tmp) and TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidine-1-oxyl) and saturation kinetics on Ph3P. The rate enhancement of (Ph3P)Rh(tmp) over Rh(tmp) was estimated to be about 11 at 70 degrees C.

  DOI：

  10.1021/om1000869

文献信息

• PREPARATION OF FUNCTIONALIZED ALKOXYAMINE INITIATOR AND ITS USE
  申请人：——

  公开号：US20030236368A1

  公开（公告）日：2003-12-25

  A one-pot process for the preparation of functional alkoxyamines of the general formula (I), 1 is disclosed. The process entails (1) reacting an oxidizing agent with a sterically hindered secondary amine to produce an aqueous phase and a nitroxyl radical (2) removing the aqueous phase and adding to the nitroxyl radical one or more vinyl monomer(s) conforming to a formula and a system which produces free radicals. Also disclosed is a process of polymerizing monomers using the functional alkoxyamine.

  披露了一种用于制备具有一般公式（I）的功能性烷氧基胺的一锅法工艺。该工艺包括：（1）使用氧化剂与空间位阻较大的二级胺反应，产生水相和硝基氧自由基；（2）移除水相，并向硝基氧自由基中加入一种或多种符合公式的乙烯基单体以及能够产生自由基的体系。还披露了一种使用功能性烷氧基胺聚合单体的工艺。
• In-situ polymerization of monoethylenically unsaturated monomers with secondary amines
  申请人：——

  公开号：US20040122270A1

  公开（公告）日：2004-06-24

  A process for the preparation of any of well-defined homopolymers, random and block copolymers is disclosed. The process that entails forming a mixture of monomers, a hindered secondary amine and an oxidizing agent is characterized in the absence of any additional free-radical initiator.

  披露了一种用于制备任何明确定义的均聚物、随机共聚物和嵌段共聚物的方法。该过程包括形成单体的混合物、受阻的二级胺和氧化剂，其特征在于没有任何额外的自由基引发剂。
• Process for the synthesis for alkoxy amines and their use in controlled radical polymerization
  申请人：——

  公开号：US20040002606A1

  公开（公告）日：2004-01-01

  A one-pot process for the preparation of alkoxyamines conforming to formulae (I) or (II), preferably (I) 1 is disclosed. The process entails (1) reacting of an oxidizing agent (A) with a sterically hindered secondary amine of the general formula (III), 2 in a water-containing medium to form a reaction product and an aqueous phase, (2) removing of the aqueous phase, and (3) (adding to the reaction product a free-radical initiator (B) under conditions that promote the decomposition of the initiator to generate free radicals. Also disclosed is a process for polymerizing monomers, the process using the alkoxyamine prepared by the inventive process.

  披露了一种用于制备符合公式(I)或(II)，最好是(I)的烷氧基胺的一锅法工艺。该工艺包括：(1)使氧化剂(A)与具有空间位阻的二级胺反应，该二级胺的通用公式为(III)，在水含介质中形成反应产物和水相，(2)移除水相，以及(3)在促进分解引发剂以产生自由基的条件下，向反应产物中添加自由基引发剂(B)。还披露了一种用于聚合单体的工艺，该工艺使用由发明工艺制备的烷氧基胺。
• One-pot process for the preparation of functionalized alkoxyamines
  申请人：Bayer Aktiengesellschaft

  公开号：EP1375457A1

  公开（公告）日：2004-01-02

  The present invention relates to a new one-pot process for the preparation of functionalized alkoxyamine initiators of the formula (I) from amines of the formula (II) and to a process of controlled radical polymerization using the functionalized alkoxyamine as initiators. In the above formulae, R1-R5 have the meanings given in the description.

  本发明涉及一种以式（II）胺为原料制备式（I）官能化烷氧胺引发剂的新的一步法工艺 式 (II) 的胺制备功能化烷氧基胺引发剂的新一锅工艺 以及使用功能化烷氧基胺作为引发剂的受控自由基聚合工艺。在上式中，R1-R5 具有说明中给出的含义。
• A new process for the synthesis of alkoxyamines active in controlled radical polymerization
  申请人：Bayer Aktiengesellschaft

  公开号：EP1375476A1

  公开（公告）日：2004-01-02

  The present invention relates to a new process for the preparation of alkoxyamine initiators and to a process of radical polymerization using the alkoxyamine initiators as intermediates.

  本发明涉及一种制备烷氧基胺引发剂的新工艺，以及以烷氧基胺引发剂为中间体的自由基聚合工艺。