2,3-Dihydroxypropyl 5-oxo-L-prolinate | 85136-14-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3-Dihydroxypropyl 5-oxo-L-prolinate
• 英文别名: 2,3-dihydroxypropyl (2S)-5-oxopyrrolidine-2-carboxylate
• CAS: 85136-14-7
• 化学式: C₈H₁₃NO₅
• 分子量: 203.19
• InChiKey: XWZPJRNVELUELY-GDVGLLTNSA-N

物化性质

• 沸点：
  496.4±45.0 °C(Predicted)
• 密度：
  1.379±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• External pharmaceutical composition
  申请人：TEIJIN LIMITED

  公开号：EP0123948A1

  公开（公告）日：1984-11-07

  A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising (A) a pharmaceutically effective amount of the pharmacologically active agent such as antiinflammatory agent, etc., and (B) a penetration enhancer of the following formula (1) wherein R, and R2 are identical or different and each represents H, a C1-25 alkyl, C2-25 alkenyl, a (C1-24 alkyl)carbonyl or a (C2-24 alkenyl)carbonyl, provided that R, and R2 are not H at the same time, or R1 and R2, taken together, may form a group of the following formula (a) in which R3 and R4 are identical or different and each represents H, C1-24 alkyl or C1-24 alkenyl.

  一种外用药物组合物，可增强药理活性剂通过温血动物皮肤或粘膜的渗透力，所述组合物包括 (A) 有效药用量的药理活性剂，如抗炎剂等，以及 (B) 下式（1）的渗透促进剂 其中 R 和 R2 相同或不同，各自代表 H、C1-25 烷基、C2-25 烯基、(C1-24 烷基)羰基或 (C2-24 烯基)羰基，但 R 和 R2 不能同时为 H，或 R1 和 R2 合在一起可形成下式（a）的基团 其中 R3 和 R4 相同或不同，各自代表 H、C1-24 烷基或 C1-24 烯基。
• Transdermal nitroglycerin patch with penetration enhancers
  申请人：SCHERING CORPORATION

  公开号：EP0417496A2

  公开（公告）日：1991-03-20

  A transdermal nitroglycerin patch exhibiting superior nitroglycerin skin penetrating characteristics comprising a percutaneous penetration enhancer is disclosed, wherein the penetration enhancer may be one or more of N-methyl-2-pyrrolidone, oleic acid, oleyl alcohol, linoleic acid, isopropyl linoleate, azone and butanediol. Also disclosed is a transdermal patch design comprising two concentric rings, wherein the concentrations of nitroglycerin and the permeability enhancer are varied.

  本发明公开了一种透皮硝化甘油贴片，该贴片具有优异的硝化甘油皮肤渗透特性，包括一种经皮渗透增强剂，其中渗透增强剂可以是 N-甲基-2-吡咯烷酮、油酸、油醇、亚油酸、亚油酸异丙酯、azone 和丁二醇中的一种或多种。 还公开了一种由两个同心环组成的透皮贴片设计，其中硝酸甘油和渗透性增强剂的浓度各不相同。
• HAIR GROWTH STIMULANT
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0768079A1

  公开（公告）日：1997-04-16

  A hair-growing agent comprising proanthocyanidin as the active ingredient. The present invention provides a hair-growing agent having strong pharmaceutical effects.

  一种以原花青素为活性成分的生发剂。本发明提供了一种具有强大药效的生发剂。
• Hair care compositions comprising higher alcohols and basic aminoacid derivatives
  申请人：Ajinomoto Co., Ltd.

  公开号：EP0830856A1

  公开（公告）日：1998-03-25

  A hair care composition with good conditioning effects and producing a desired feeling upon use comprises a higher alcohol in combination with a basic amino acid derivative formed by the reaction of a glycidyl ether or a 1,2-epoxyalkane ( both of which are epoxy compounds) with a basic amino acid. A cationic polymer or an anionic surface active agent and/or an ampholytic surface active agent may be used in addition to the above-mentioned components. In this way the use of alkyl quaternary ammonium salts, which are problematic in the irritation, the biodegradability and such like, may be avoided.

  一种护发组合物具有良好的调理效果，使用时能产生理想的感觉，它由一种高级醇和一种碱性氨基酸衍生物组成，碱性氨基酸衍生物是由缩水甘油醚或 1,2-环氧烷烃（两者都是环氧化合物）与碱性氨基酸反应生成的。除上述成分外，还可使用阳离子聚合物或阴离子表面活性剂和/或两性表面活性剂。这样就可以避免使用在刺激性、生物降解性等方面有问题的烷基季铵盐。
• HAIR GROWTH STIMULANTS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1214928A1

  公开（公告）日：2002-06-19

  A hair-growing agent comprising, as active ingredients, one or more members selected from the group consisting of lysophosphatidic acids, and phosphatidic acids wherein the fatty acid residue moiety consists only of straight-chain fatty acid residues having an even number of carbon atoms.

  一种生发剂，其活性成分包括从溶血磷脂酸和磷脂酸组成的组中选出的一种或多种成员，其中脂肪酸残基分子仅由具有偶数个碳原子的直链脂肪酸残基组成。