1-Iodoethyl 2-ethylbutanoate | 89296-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Iodoethyl 2-ethylbutanoate
• CAS: 89296-78-6
• 化学式: C₈H₁₅IO₂
• 分子量: 270.11
• InChiKey: VQKHIYQILKBSLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel carbapenem derivatives
  申请人：——

  公开号：US20030149016A1

  公开（公告）日：2003-08-07

  Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- Pseudomonas aeruginosa , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof: 1

  本发明公开了一种新型碳青霉烯衍生物，其在碳青霉烯环上的2位上具有取代咪唑[5,1-b]噻唑基团，对β-内酰胺酶产生的细菌、MRSA、耐药性假单胞菌、PRSP、肠球菌和流感病毒具有高抗菌活性，并对DHP-1具有高稳定性。根据本发明，提供了由式(I)表示的化合物，或其在碳青霉烯环上的3位处的药理学上可接受的盐或酯：1。
• 3-Substituted vinyl cephalosporin derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0408034A1

  公开（公告）日：1991-01-16

  3-Substituted vinyl cephalosporin derivatives represented by the following formula: wherein R1 represents a hydroxyl or lower alkoxyl group, X represents a nitrogen atom or a group represented by the formula -CH =, R2 represents a carboxyl group or a carboxyl group protected with a protecting group, and R3 is as defined herein, and pharmaoeutically acceptable salts thereof are potent antibacterial agents. Processes for their preparation, intermediates in such processes, and antibacterial compositions containing them as active ingredients are also described.

  3-由下式代表的取代乙烯基头孢菌素衍生物： 其中 R1 代表羟基或低级烷氧基，X 代表氮原子或由式 -CH = 代表的基团，R2 代表羧基或由保护基团保护的羧基，R3 如本文所定义，其药用盐是强效抗菌剂。此外，还介绍了制备它们的工艺、这些工艺的中间体以及含有它们作为活性成分的抗菌组合物。
• 7-Acyl-3-(substituted carbamoyloxy) cephem compounds, use thereof and process for their preparation
  申请人：Eisai Co., Ltd.

  公开号：EP0484966A2

  公开（公告）日：1992-05-13

  A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): wherein A means a -CH= or -N= group; R¹ denotes a hydroxyl, lower alkoxyl, fluorine-substituted lower alkoxyl or protected hydroxyl group; R² and R³ are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R² is a hydrogen atom and R³ is a lower alkoxyl or alkyl group optionally substituted by one or more halogen atoms, or the group means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R⁴ denotes a carboxyl or protected carboxyl group; or a pharmaceutically acceptable salt thereof; and a process for the preparation thereof; use thereof as well as an antibacterial composition containing the above cephem compound.

  由下式（1）代表的 7-酰基-3-取代氨基甲酰氧基头孢化合物： 其中 A 表示 -CH= 或 -N= 基团；R¹ 表示羟基、低级烷氧基、氟取代的低级烷氧基或受保护的羟基；R² 和 R³ 相同或不同，且各自表示低级烷基、羟基取代的低级烷基、氨基甲酰基取代的低级烷基或氰基取代的低级烷基，R² 是氢原子，R³ 是低级烷氧基或烷基，可选择被一个或多个卤素原子或基团取代。 R⁴表示羧基或受保护的羧基；或其药学上可接受的盐；及其制备方法；其用途以及含有上述 cephem 化合物的抗菌组合物。
• Cephem derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0761671A1

  公开（公告）日：1997-03-12

  A compound represented by the following formula (9): wherein R5 represents an amino or protected amino group and Y represents a hydrogen atom, a lower alkyl group, a halogen atom or a nitro group, or a salt thereof.

  由下式(9)代表的化合物： 其中 R5 代表氨基或受保护的氨基，Y 代表氢原子、低级烷基、卤素原子或硝基，或其盐。
• 7-acyl-3-(substituted carbamoyloxy) cephem compounds, use thereof and process for their preparation
  申请人：Eisai Co., Ltd.

  公开号：EP1074554A2

  公开（公告）日：2001-02-07

  A compound represented by the following formula (1a): a process for the preparation thereof, an antibacterial composition comprising the same and the use thereof for the preparation of a medicament and for the synthesis of related cephem compounds.

  一种由下式（1a）表示的化合物： 其制备方法、包含其成分的抗菌组合物，以及将其用于制备药物和合成相关的头孢化合物。