(2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoate
• 化学式: C9H9N2O5-
• 分子量: 225.18
• InChiKey: FBTSQILOGYXGMD-LURJTMIESA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 3-Nitrotyrosinated fibrinogen as a diagnostic marker in ischemic stroke and uses thereof
  申请人：Universitat Pompeu-Fabra

  公开号：EP2315032A1

  公开（公告）日：2011-04-27

  An in vitro method for diagnosing an ischemic stroke in a patient, comprising measuring the amount of 3-nitrotyrosinated fibrinogen in the patient, which further comprises comparing the obtained value with known value(s) associated with an ischemic stroke and/or control value(s). And also a method of deciding or recommending whether to iniciate pharmacological treatment of a patient suspected of suffering an ischemic stroke which method comprises: a) measuring, in vitro, the amount of 3-nitrotyrosinated fibrinogen in the patient; b) diagnosing the ischemic stroke by comparing the value obtained in step (a) with known value(s) associated with an ischemic stroke and/or control value(s), c) wherein, ca) if the patient is diagnosed of suffering an ischemic stroke, then the initiation of the treatment is recommended, and/or cb) if the patient is diagnosed of not suffering an ischemic stroke, then refraining from the treatment is recommended, optionally in consideration of the result of an examination of the patient by a neurologist.

  一种诊断患者缺血性中风的体外方法，包括测量患者体内 3-硝基酪氨酸化纤维蛋白原的量，该方法还包括将所获值与与缺血性中风相关的已知值和/或对照值进行比较。还有一种决定或建议是否对疑似缺血性中风患者进行药物治疗的方法，该方法包括a) 在体外测量患者体内 3-硝基酪氨酸化纤维蛋白原的含量；c) 其中，ca) 如果患者被诊断为缺血性中风，则建议开始治疗，和/或 cb) 如果患者被诊断为非缺血性中风，则建议不进行治疗，可选择考虑神经科医生对患者的检查结果。
• [EN] 3-NITROTYROSINATED FIBRINOGEN AS A DIAGNOSTIC MARKER IN ISCHEMIC STROKE AND USES THEREOF<br/>[FR] FIBRINOGÈNE 3-NITROTYROSINÉ EN TANT QUE MARQUEUR DIAGNOSTIQUE D'UN ACCIDENT VASCULAIRE CÉRÉBRAL ISCHÉMIQUE ET SES UTILISATIONS
  申请人：UNI POMPEU FABRA

  公开号：WO2011048080A1

  公开（公告）日：2011-04-28

  An in vitro method for diagnosing an ischemic stroke in a patient, comprising measuring the amount of 3-nitrotyrosinated fibrinogen in the patient, which further comprises comparing the obtained value with known value(s) associated with an ischemic stroke and/or control value(s). And also a method of deciding or recommending whether to initiate pharmacological treatment of a patient suspected of suffering an ischemic stroke which method comprises: a) measuring, in vitro, the amount of 3-nitrotyrosinated fibrinogen in the patient; b) diagnosing the ischemic stroke by comparing the value obtained in step (a) with known value(s) associated with an ischemic stroke and/or control value(s), c) wherein, ca) if the patient is diagnosed of suffering an ischemic stroke, then the initiation of the treatment is recommended, and/or cb) if the patient is diagnosed of not suffering an ischemic stroke, then refraining from the treatment is recommended, optionally in consideration of the result of an examination of the patient by a neurologist.