{[2-(5-甲基-2,4-二羰基-3,4-二氢嘧啶-1(2H)-基)乙氧基]甲基}膦酸 | 116455-16-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: {[2-(5-甲基-2,4-二羰基-3,4-二氢嘧啶-1(2H)-基)乙氧基]甲基}膦酸
• 英文名称: Phosphonic acid, ((2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)ethoxy)methyl)-
• 英文别名: 2-(5-methyl-2,4-dioxopyrimidin-1-yl)ethoxymethylphosphonic acid
• CAS: 116455-16-4
• 化学式: C₈H₁₃N₂O₆P
• 分子量: 264.17
• InChiKey: RCQMOSJJIVCPJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-[2-(diethoxyphosphorylmethoxy)ethyl]-5-methylpyrimidine-2,4-dione 、 三甲基溴硅烷 生成 {[2-(5-甲基-2,4-二羰基-3,4-二氢嘧啶-1(2H)-基)乙氧基]甲基}膦酸
  参考文献：
  名称：

  HOLY, ANTONIN;ROSENBERG, IVAN;DVORAKOVA, HANA;DECLERCQ, ERIK, NUCLEOSIDES AND NUCLEOTIDES, 7,(1988) N-6, C. 667-670

  摘要：

  DOI：

文献信息

• [EN] LEWIS ACID MEDIATED SYNTHESIS OF CYCLIC ESTERS<br/>[FR] SYNTHESE D'ESTERS CYCLIQUES INDUITE PAR L'ACIDE DE LEWIS
  申请人：METABASIS THERAPEUTICS INC

  公开号：WO2005123729A1

  公开（公告）日：2005-12-29

  Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.

  描述了从1,3-二醇合成环磷酸二酯的方法，其中通过在Lewis酸存在下反应手性1,3-二醇和活化磷酸制得环磷酸二酯。
• ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
  申请人：The Regents of the University of California

  公开号：US20170002033A1

  公开（公告）日：2017-01-05

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开涉及用于治疗病毒性疾病和癌症的组合物和方法，其中包括脂溶性抗病毒和抗癌无环核苷酸膦酸二酯，其制备方法以及使用这些化合物治疗病毒性疾病和癌症的方法。
• Acyclic nucleoside phosphonate diesters
  申请人：The Regents of the University of California

  公开号：US10076533B2

  公开（公告）日：2018-09-18

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开主要涉及治疗病毒性疾病和癌症的组合物和方法。本发明公开了亲脂性抗病毒和抗癌无环核苷膦酸二酯、其制备方法以及使用该化合物治疗病毒性疾病和癌症的方法。
• Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
  申请人：Maziasz Timothy

  公开号：US20050026902A1

  公开（公告）日：2005-02-03

  The present invention provides compositions and methods for the treatment of human immunodeficiency virus (HIV) infection as well as HIV associated diseases and related disorders. More particularly, the invention provides a combination therapy for the treatment of HIV infection as well as HIV associated diseases and related disorders comprising the administration to a subject of an anti-human immunodeficiency virus agent in combination with a cyclooxygenase-2 selective inhibitor or an isomer or a pharmaceutically acceptable salt, ester, or prodrug thereof.

  本发明提供了治疗人类免疫缺陷病毒（HIV）感染以及HIV相关疾病和相关紊乱的组合物和方法。更具体地说，本发明提供了一种治疗HIV感染以及HIV相关疾病和相关紊乱的组合疗法，包括向受试者施用抗人类免疫缺陷病毒制剂与环氧化酶-2选择性抑制剂或其异构体或其药学上可接受的盐、酯或原药组合。
• Lewis acid mediated synthesis of cyclic esters
  申请人：Martin V. Kevin

  公开号：US20050282782A1

  公开（公告）日：2005-12-22

  Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.

  本发明描述了从 1,3-二醇合成环膦酸二酯的方法，其中环膦酸二酯是通过手性 1,3-二醇和活化膦酸在路易斯酸存在下反应生成的。