ethyl (1S,2R)-2-methylcyclopropane-1-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl (1S,2R)-2-methylcyclopropane-1-carboxylate
• 化学式: C₇H₁₂O₂
• 分子量: 128.17
• InChiKey: JWYSLVLBKXDZCW-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• c-Met modulators and methods of use
  申请人：Exelixis, Inc.

  公开号：EP2609919A2

  公开（公告）日：2013-07-03

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了调节蛋白激酶酶活性的化合物，用于调节细胞活动，如增殖、分化、细胞程序性死亡、迁移和化学侵袭。更具体地说，本发明提供了抑制、调节和/或调控激酶受体（尤其是 c-Met、KDR、c-Kit、flt-3 和 flt-4）的喹唑类和喹啉类化合物、与上述细胞活动变化有关的信号转导通路、含有这些化合物的组合物以及使用它们治疗激酶依赖性疾病和病症的方法。本发明还提供了制造上述化合物的方法，以及含有这些化合物的组合物。