N-{L-3-trans-[2-(Pyrazin-2-yl)ethylcarbamoyl]oxirane-2-carbonyl}-L-phenylalanine dimethylamide | 215099-16-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{L-3-trans-[2-(Pyrazin-2-yl)ethylcarbamoyl]oxirane-2-carbonyl}-L-phenylalanine dimethylamide
• 英文别名: (2S,3S)-2-N-[(2S)-1-(dimethylamino)-1-oxo-3-phenylpropan-2-yl]-3-N-(2-pyrazin-2-ylethyl)oxirane-2,3-dicarboxamide
• CAS: 215099-16-4
• 化学式: C₂₁H₂₅N₅O₄
• 分子量: 411.461
• InChiKey: IIKXWIGVKSPNDO-BZSNNMDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF
  申请人：TAIHO PHARMACEUTICAL COMPANY, LIMITED

  公开号：EP0921122A1

  公开（公告）日：1999-06-09

  The invention relates an epoxysuccinamide derivative represented by a formula (I): wherein R1 represents a hydrogen atom, an alkyl or aminoalkyl group, R2 represents an aminoalkyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R1 and R2 may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R3 and R4 are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient. This compound has a specific inhibitory activity for cathepsin L and family enzymes thereof, and is useful as an agent for preventing and treating metabolic osteopathy such as osteoporosis and hypercalcemia.

  本发明涉及一种环氧琥珀酰胺衍生物，由式（I）表示 由式(I)表示：其中 R1 代表氢原子、烷基或氨基烷基，R2 代表可被取代的氨基烷基、可被取代的芳基、可被取代的杂环基、可被取代的芳烷基或被可被取代的杂环取代的烷基、或 R1 和 R2 可与相邻的氮原子一起形成可被取代的含氮杂环，且 R3 和 R4 彼此相同或不同，并独立代表氢原子或烷基或芳烷基，或其盐，其制备方法，以及包含这种衍生物或盐作为有效成分的药物。该化合物对 cathepsin L 及其家族酶具有特异性抑制活性，可作为预防和治疗骨质疏松症和高钙血症等代谢性骨病的药物。
• US6110967A
  申请人：——

  公开号：US6110967A

  公开（公告）日：2000-08-29