2-Hydroxyoxane-2-carboxylic acid | 776255-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-Hydroxyoxane-2-carboxylic acid
• CAS: 776255-60-8
• 化学式: C₆H₁₀O₄
• 分子量: 146.14
• InChiKey: SXTJHIPACWRISC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pharmaceutical composition
  申请人：KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

  公开号：US10993960B1

  公开（公告）日：2021-05-04

  A pharmaceutical composition includes polymer units α and β, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units α and β are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit α has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit β has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.

  一种药物组合物包括聚合物单元 α 和 β（每个单元都有一条与阳离子聚合物链结合的亲水聚合物链）以及一种药物。聚合物单元 α 和 β 沿径向排列，使阳离子聚合物链向内，亲水聚合物链向外，从而形成胶束，药物封装在胶束中。聚合物单元 α 的阳离子聚合物链的侧链上有一个苯硼酸基团，聚合物单元 β 的阳离子聚合物链的侧链上有一个苯硼酸结合位点。苯硼酸基团和苯硼酸结合位点形成一种交联结构，在酸性环境中和/或在有竞争性结合物质存在的情况下可以解离。
• VERFAHREN ZUR HERSTELLUNG VON MIKROPARTIKELN, DIE MIT EINEM AKTIVSTOFF BELADEN SIND
  申请人：BASF SE

  公开号：EP3873658A1

  公开（公告）日：2021-09-08
• EP300/CREBBP INHIBITOR
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20210171520A1

  公开（公告）日：2021-06-10

  The present invention provides a compound having excellent histone acetyl transferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q 1 , ring Q 2 , R 1 , R 2 , R 3 and R 4 respectively have the same meanings as defined in the specification.
• PHARMACEUTICAL COMPOSITION
  申请人：KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION

  公开号：US20210187005A1

  公开（公告）日：2021-06-24

  A pharmaceutical composition includes polymer units α and β, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units α and β are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit α has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit β has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.
• US6120788A
  申请人：——

  公开号：US6120788A

  公开（公告）日：2000-09-19