acetic acid;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | 106576-79-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: acetic acid;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• CAS: 106576-79-8
• 化学式: C22H28N2O4
• 分子量: 384.5
• InChiKey: LFRDQVMJPQDWTM-DSXUQNDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.26
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  82.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PHOSPHORAMIDATES ENRICHIS EN DIASTÉRÉO-ISOMÈRES DE COMPOSÉS DE NUCLÉOSIDES, DESTINÉS AU TRAITEMENT D'INFECTIONS VIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014008236A1

  公开（公告）日：2014-01-09

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备具有化学式I的对映异构体富集的核苷磷酰胺酯的方法。
• PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150183818A1

  公开（公告）日：2015-07-02

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备式I的对映体富集核苷酸磷酰胺酯的方法：
• [EN] STEREOSELECTIVE MANUFACTURE OF SELECTED PURINE PHOSPHORAMIDATES<br/>[FR] PRODUCTION STÉRÉOSÉLECTIVE DE PHOSPHORAMIDATES DE PURINE SÉLECTIONNÉS
  申请人：ATEA PHARMACEUTICALS INC

  公开号：WO2022040473A1

  公开（公告）日：2022-02-24

  The present invention provides stereoselective processes of manufacture for the phosphoramidate nucleotide Compound 1 or a pharmaceutically acceptable salt thereof.

  本发明提供了制造磷酰胺酰核苷化合物1或其药学上可接受的盐的立体选择性过程。
• Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid
  申请人：TEVA PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0581169A1

  公开（公告）日：1994-02-02

  D(+)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid, an important intermediate in the synthesis of diltiazem hydrochloride, is obtained in better yields and high optical purity by a novel resolution process comprising the reaction of 2 moles of the (±) racemic acid with 1 mole of quinine and 1 mole of a base in a suitable polar solvent system to form a salt of the D(+) acid and quinine which precipitates; separating said salt and decomposing it with a strong base.

  D(+)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid 是合成盐酸地尔硫卓的一种重要中间体，通过一种新的解析工艺可以获得较高的产率和光学纯度，该工艺包括：在合适的极性溶剂体系中，将 2 摩尔的(±)外消旋酸与 1 摩尔的奎宁和 1 摩尔的碱反应，形成 D(+) 酸和奎宁的盐，并沉淀下来；分离所述盐并用强碱分解。
• US5302741A
  申请人：——

  公开号：US5302741A

  公开（公告）日：1994-04-12