D-Argininamide, D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)- | 228546-92-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-Argininamide, D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl)-
• 英文别名: (2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]hexanamide
• CAS: 228546-92-7
• 化学式: C₃₆H₄₉N₉O₄
• 分子量: 671.8
• InChiKey: DBOGGOVKHSCMNB-OMRVPHBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  49
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  220
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• Methods and compositions for treating vasomotor symptoms
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US11083726B2

  公开（公告）日：2021-08-10

  The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.

  本公开总体上涉及用于治疗或限制受试者血管运动症状发展的组合物和方法。
• Method For Elevating Prolactin in Mammals
  申请人：Menzaghi Frederique

  公开号：US20090312271A1

  公开（公告）日：2009-12-17

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• Method For Elevating Prolactin In Mammals
  申请人：Menzaghi Frederique

  公开号：US20130012431A1

  公开（公告）日：2013-01-10

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• METHODS AND COMPOSITIONS FOR TREATING VASOMOTOR SYMPTOMS
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20150272927A1

  公开（公告）日：2015-10-01

  The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.
• Methods and Compositions for Treating Vasomotor Symptoms
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20170020855A1

  公开（公告）日：2017-01-26

  The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.