1-(6-(hydroxymethyl)-1,4-oxaselenan-2-yl)pyrimidine-2,4(1H,3H)-dione | 1140308-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(6-(hydroxymethyl)-1,4-oxaselenan-2-yl)pyrimidine-2,4(1H,3H)-dione
• 英文别名: 1-[(2R,6R)-6-(hydroxymethyl)-1,4-oxaselenan-2-yl]pyrimidine-2,4-dione
• CAS: 1140308-91-3
• 化学式: C₉H₁₂N₂O₄Se
• 分子量: 291.165
• InChiKey: YZSVREQVRNZNCI-HTRCEHHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.03
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1,4-oxaselenan-2-yl)pyrimidine-2,4(1H,3H)-dione 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.0h， 以87.6%的产率得到1-(6-(hydroxymethyl)-1,4-oxaselenan-2-yl)pyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Novel Selenonucleosides

  摘要：

  A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

  DOI：

  10.1080/15257770802088803

文献信息

• Synthesis and Biological Evaluation of Novel Selenonucleosides
  作者：Yao Chen、Yingdan Peng、Jiancun Zhang、Lei Fu

  DOI：10.1080/15257770802088803

  日期：2008.8.11

  A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.