TPT | 199586-29-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: TPT
• 英文别名: L-Thr-L-Pro-L-Thr；L-Threonyl-L-prolyl-L-threonine；(2S,3R)-2-[[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
• CAS: 199586-29-3
• 化学式: C₁₃H₂₃N₃O₆
• 分子量: 317.342
• InChiKey: GVMXJJAJLIEASL-ZJDVBMNYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  153
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  C₃₂H₃₅ClN₃O₆Pol 生成 TPT
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• SERUM-FREE CRYOPRESERVATION SOLUTION AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES

  公开号：US20220142148A1

  公开（公告）日：2022-05-12

  A serum-free cryopreservation solution contains a biomimetic ice control material, a polyol, a water-soluble sugar, and a buffer solution margin. The bionic ice control material can be polyvinyl alcohol or an amino acid compound. The cryopreservation liquid of the present invention uses the bionic ice control material as the main component, does not contain serum, has low toxicity, and can achieve a cell survival rate that is the same as, or higher than, existing cryopreservation solutions.
• BIOMIMETIC ICE-INHIBITING MATERIAL AND CRYOPRESERVATION SOLUTION COMPRISING SAME
  申请人：INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES

  公开号：US20220192179A1

  公开（公告）日：2022-06-23

  A biomimetic ice growth inhibition material is prepared. by constructing a library for structures of compound molecules, with the compound molecules comprising a hydrophilic group and an ice-philic group, by evaluating the spreading performance of each compound molecule at an ice-water interface by adopting molecular dynamics simulation (MD simulation), and by screening the compound molecules with the desired affinities for ice and water. The present invention firstly provides the mechanism of the affinities of the ice growth inhibition material for ice and water, introduces MD simulation into the molecular structure design of the ice growth inhibition material, evaluates the affinities of the designed ice growth inhibition material for ice and water through MD simulation, predicts the ice growth inhibition performance of the ice growth inhibition material, and can realize the optimization of the structure.
• DMSO-FREE CRYOPRESERVATION SOLUTION AND PREPARATION METHOD AND USE THEREOF
  申请人：PEKING UNIVERSITY THIRD HOSPITAL

  公开号：US20220167610A1

  公开（公告）日：2022-06-02

  A cryopreservation solution contains 0.01-50.0 g of bionic ice control materials, 5.0-30 mL of polyols, 1-30 g of water-soluble sugar, and 0-30 mL of serum, and a buffer in every 100 mL of the cryopreservation solution. It does not contain DMSO. When being used for the cryopreservation of mouse oocytes and embryos, the solution may achieve the same or an even higher cell and tissue survival rate and functional expression stability as or than a commercial cryopreservation solution (containing 15% DMSO), and has high preservation efficiency. The cryopreservation solution without DMSO or serum reduces parasitic biological contaminants in the commercial cryopreservation solution containing serum currently used in clinical practice.