(2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane | 1067185-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane
• 英文别名: tert-butyl-[2-[(4S,6S)-6-[(E)-3-[(4S,6S)-2,2-dimethyl-6-(phenylmethoxymethyl)-1,3-dioxan-4-yl]prop-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl]ethoxy]-diphenylsilane
• CAS: 1067185-79-8
• 化学式: C₄₁H₅₆O₆Si
• 分子量: 672.978
• InChiKey: ZDAQXOBPDVMFSD-SXJZGOIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.94
• 重原子数：
  48
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-(2-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethylsulfonyl)-1-phenyl-1H-tetrazole 、 (4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxane-4-carbaldehyde 在 lithium hexamethyldisilazane 、 18-冠醚-6 作用下， 以 乙二醇二甲醚 、 正己烷 为溶剂， 反应 38.0h， 生成 (2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane 、 (2-((4S,6S)-6-(3-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)prop-1-enyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethoxy)(tert-butyl)diphenylsilane
  参考文献：
  名称：

  A first convergent synthesis of the polyolic fragment of the antifungal pentaene macrolide strevertene A

  摘要：

  The C(4-14) polyolic segment of antifungal macrolide strevertenes has been synthesized for the first time in protected form, incorporating four stereogenic centers. The synthetic strategy developed is based on the connection of two subunits prepared starting from the same chiral building block. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.022

文献信息

• A first convergent synthesis of the polyolic fragment of the antifungal pentaene macrolide strevertene A
  作者：Carlo Bonini、Lucia Chiummiento、Maria Funicello、Paolo Lupattelli、Valeria Videtta

  DOI：10.1016/j.tetlet.2008.07.022

  日期：2008.9

  The C(4-14) polyolic segment of antifungal macrolide strevertenes has been synthesized for the first time in protected form, incorporating four stereogenic centers. The synthetic strategy developed is based on the connection of two subunits prepared starting from the same chiral building block. (C) 2008 Elsevier Ltd. All rights reserved.