Argatroban, 21S- | 1050351-64-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Argatroban, 21S-
• 英文别名: (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid;hydrate
• CAS: 1050351-64-8
• 化学式: C23H38N6O6S
• 分子量: 526.7
• InChiKey: AIEZTKLTLCMZIA-RZLLGALYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.12
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  190
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Argatroban preparations for ophthalmic use
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0565897A1

  公开（公告）日：1993-10-20

  The use of argatroban in the preparation of a medicament for preventing fibrin formation in the anterior chamber of mammals is provided. A medicament prepared by using argatroban may be in the form of an irrigating solution, an eye drop and a drip infusion in order to prevent fibrin formation in the anterior chamber.

  本研究提供了使用阿加曲班制备防止哺乳动物前房纤维蛋白形成的药物的方法。使用阿加曲班制备的药物可采用冲洗液、滴眼液和滴注的形式，以防止前房纤维蛋白的形成。
• Aqueous compositions comprising argatroban and cyclodextrin or caffeine
  申请人：Senju Pharmaceutical Co., Ltd.

  公开号：EP0621036A1

  公开（公告）日：1994-10-26

  An aqueous agent comprising at least one arginine amide selected from the group consisting of (2R,4R)-4-methyl-1-[N²-((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid, monohydrate thereof and pharmacologically acceptable salts thereof, and at least one compound selected from the group consisting of cyclodextrin and caffeine; a method for improving the solubility of arginine amide in water, comprising adding at least one compound selected from the group consisting of cyclodextrin and caffeine; and a method for stabilizing arginine amide in water, comprising adding caffeine. According to the present invention, the solubility of arginine amide in water can be enhanced to, for example, a concentration permitting inhibition of fibrin formation at the time of entoptic operation. In addition, the stability of arginine amide in water can be enhanced with less irritation of the eye.

  一种水剂，包含至少一种选自由(2R,4R)-4-甲基-1-[N²-((RS)-3-甲基-1,2,3,4-四氢-8-喹啉磺酰基)-L-精氨酰]-2-哌啶羧酸、其一水合物和药理学上可接受的盐组成的组，以及至少一种选自由环糊精和咖啡因组成的组的化合物；一种提高精氨酸酰胺在水中溶解度的方法，包括添加至少一种选自环糊精和咖啡因组成的组的化合物；以及一种稳定精氨酸酰胺在水中溶解度的方法，包括添加咖啡因。根据本发明，精氨酸酰胺在水中的溶解度可提高到例如在内窥镜操作时可抑制纤维蛋白形成的浓度。此外，还可提高精氨酸酰胺在水中的稳定性，减少对眼睛的刺激。