Boc-QAR-AMC

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-QAR-AMC
• 英文别名: Boc-Gln-Ala-Arg-MCA；Boc-Gln-Ala-Arg-AMC；Boc-Gln-Ala-Arg-7-Amino-4-Methylcoumarin；tert-butyl N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamate
• 化学式: C₂₉H₄₂N₈O₈
• 分子量: 630.701
• InChiKey: LQSLBVXESNRILG-VDGAXYAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  45
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  259
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Vaccine
  申请人：GlaxoSmithKline Biologicals SA

  公开号：EP1927598A1

  公开（公告）日：2008-06-04

  The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoides dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.

  本发明涉及经过密码子优化的多核苷酸，这些多核苷酸可在哺乳动物细胞中高效表达，并编码来自 Dermaphagoides 尘螨的昆虫蛋白质。特别是，优化密码子多核苷酸编码来自 Dermaphagoides pteronyssinus 的蛋白质，如 DerP1 或 proDerP1。本发明还提供了制备包含表达密码子优化多核苷酸的药物组合物的方法，以及包含它们的载体和转化宿主细胞。
• Markers for abnormal cells
  申请人：Georgetown University

  公开号：US10175238B2

  公开（公告）日：2019-01-08

  The present invention relates to methods of determining the presence or absence of abnormal lymphoid cells or abnormal myeloid cells in a cell sample, with the methods comprising subjecting the cell sample to conditions that will activate any inactive matriptase present in the cell sample and measuring the levels of activated matriptase in the cell sample. Once measured, these levels can then be compared to control levels of active matriptase to determine if the cell sample has elevated levels of activated matriptase over control levels of active matriptase. An elevation in the levels of activated matriptase in the cell sample is indicative that the cell sample contains abnormal lymphoid cells or abnormal myeloid cells.

  本发明涉及确定细胞样本中是否存在异常淋巴细胞或异常髓系细胞的方法，其方法包括将细胞样本置于可激活细胞样本中任何非活性凋亡酶的条件下，并测量细胞样本中活化凋亡酶的水平。测量后，可将这些水平与活性马特普酶的对照水平进行比较，以确定细胞样本中的活性马特普酶水平是否高于活性马特普酶的对照水平。细胞样本中活性凋亡酶水平的升高表明细胞样本中含有异常淋巴细胞或异常髓系细胞。
• Codon optimised recombinant dermaphagoides allergens
  申请人：——

  公开号：US20030138441A1

  公开（公告）日：2003-07-24

  The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoids dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.

  本发明涉及经过密码子优化的多核苷酸，这些多核苷酸可在哺乳动物细胞中高效表达，并编码来自 Dermaphagoids 尘螨的昆虫蛋白质。特别是，优化的密码子多核苷酸编码一种来自 Dermaphagoides pteronyssinus 的蛋白质、 如 DerP1 或 proDerP1。本发明还提供了制备包含表达密码子优化多核苷酸的药物组合物的方法，以及包含它们的载体和转化宿主细胞。
• Synthetic substrates for prostasin
  申请人：——

  公开号：US20040018580A1

  公开（公告）日：2004-01-29

  Synthetic peptide substrates of prostasin, a method for synthesizing them and a prostasin assay are provided.

  本研究提供了前列腺素的合成肽底物、合成方法和前列腺素检测方法。
• Derp1 and proderp1 allergen derivatives
  申请人：——

  公开号：US20040234538A1

  公开（公告）日：2004-11-25

  The present invention provides a novel treatment for allergy comprising the provision of a recombinant DerP1/ProDerP1 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.

  本发明提供了一种新型过敏治疗方法，包括提供一种具有低过敏活性的重组 DerP1/ProDerP1 过敏原衍生物。本发明还提供了由所述突变过敏原组成的药物组合物，该组合物可刺激过敏或天真个体的 Th1 型免疫反应，从而降低与野生型过敏原接触后发生过敏反应的可能性。