(R,S)-hydroxy Ramelteon Metabolite M-II

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (R,S)-hydroxy Ramelteon Metabolite M-II
• 英文别名: 2-hydroxy-N-[2-(2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]propanamide
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.34
• InChiKey: FGFNIJYHXMJYJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ORALLY DISPERSIBLE TABLET
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2765985A1

  公开（公告）日：2014-08-20
• [EN] ORALLY DISPERSIBLE TABLET<br/>[FR] COMPRIMÉ DISPERSIBLE PAR VOIE ORALE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2013054582A1

  公开（公告）日：2013-04-18

  The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.