N,N'-bis(2,3-dihydroxybenzoyl)-N''-hexanoyltren | 1120366-33-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis(2,3-dihydroxybenzoyl)-N''-hexanoyltren
• 英文别名: N-[2-[2-[(2,3-dihydroxybenzoyl)amino]ethyl-[2-(hexanoylamino)ethyl]amino]ethyl]-2,3-dihydroxybenzamide
• CAS: 1120366-33-7
• 化学式: C₂₆H₃₆N₄O₇
• 分子量: 516.594
• InChiKey: QORASAFRNIETBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  37
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  172
• 氢给体数：
  7
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  C₃₀H₄₄N₄O₇ 在 三溴化硼 、 甲醇 作用下， 以 二氯甲烷 为溶剂， 生成 N,N'-bis(2,3-dihydroxybenzoyl)-N''-hexanoyltren
  参考文献：
  名称：

  Catechols as Membrane Anion Transporters

  摘要：

  We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.

  DOI：

  10.1021/ja809733c

文献信息

• Catechols as Membrane Anion Transporters
  作者：Sofya Kostina Berezin、Jeffery T. Davis

  DOI：10.1021/ja809733c

  日期：2009.2.25

  We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.