L-Glutaminyl-L-tryptophan | 66851-83-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Glutaminyl-L-tryptophan
• 英文别名: (2S)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
• CAS: 66851-83-0
• 化学式: C₁₆H₂₀N₄O₄
• 分子量: 332.35
• InChiKey: ZQFAGNFSIZZYBA-AAEUAGOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
  申请人：——

  公开号：US20030087830A1

  公开（公告）日：2003-05-08

  Low molecular weight components extracted from shark cartilage and complexes made of copper with amino acid or dipeptide units or analogs thereof are disclosed. Methods are disclosed for the inhibition of angiogenesis (neovascularization) in an animal through the administration of these complexes, which results in treating angiogenesis-dependent diseases.

  从鲨鱼软骨中提取的低分子量成分以及与氨基酸或二肽单位或其类似物形成的铜络合物被揭示。通过给动物注射这些络合物的方法被揭示，从而抑制血管生成（新血管生成），从而治疗依赖于血管生成的疾病。
• Compositions to improve tic disorders
  申请人：Ozeki Makoto

  公开号：US20060217321A1

  公开（公告）日：2006-09-28

  Tic disorders can be improved by administering theanine, an amino acid that crosses the blood-brain barrier, or a dipeptide consisting of theanine and a different amino acid. In addition, these compositions can be added to foods and drinks or pharmaceuticals.

  滴状障碍可以通过给予茶氨酸改善，这是一种可以穿过血脑屏障的氨基酸，或者是由茶氨酸和另一种氨基酸组成的二肽。此外，这些组合物可以添加到食品和饮料或药品中。
• [EN] CRYSTAL FORMS OF GOLOTIMOD AND PROCESS FOR ITS MANUFACTURING<br/>[FR] FORMES CRISTALLINES DE GOLOTIMOD ET PROCÉDÉ POUR SA FABRICATION
  申请人：APOTEX TECHNOLOGIES INC

  公开号：WO2013155592A1

  公开（公告）日：2013-10-24

  Crystalline forms of golotimod of the chemical structure: (I) and processes for their manufacture are provided.

  提供了化学结构为（I）的golotimod的晶体形式及其制造过程。
• Nutrient compositions containing peptides
  申请人：CLINTEC NUTRITION COMPANY

  公开号：EP0457314A1

  公开（公告）日：1991-11-21

  Nutrient compositions comprise an aqueous solution of at least one dipeptide with an N-terminal amino acid selected from glutamine, aspargine, tyrosine, tryptophan, and aspargine. The C-terminal amino acid is alanine, glycine, tryptophan, arginine, proline or serine. The nutritional compositions contain from about 0.1 to 25.0 percent by weight of oligopeptides, preferably about 0.5 to 5.0 percent by weight.

  营养组合物包含至少一种二肽的水溶液，其 N 端氨基酸选自谷氨酰胺、天门冬氨酸、酪氨酸、色氨酸和天门冬氨酸。 C 端氨基酸为丙氨酸、甘氨酸、色氨酸、精氨酸、脯氨酸或丝氨酸。营养组合物含有约 0.1%至 25.0%（按重量计）的低聚肽，最好是约 0.5%至 5.0%（按重量计）。
• PHARMACEUTICAL COMPOSITION FOR TREATING VIRAL DISEASES
  申请人：Obshestvo S Ogranichennoj Otvetstvennostju "citoNIR"

  公开号：EP2604264A1

  公开（公告）日：2013-06-19

  The invention relates to medicine, and specifically to medicinal preparations on the basis of peptides. The composition comprises 0.01 - 0.03 mg per therapeutic dose of an inducer of endogenous interferon - a dipeptide of glutamic acid, selected from the group consisting of alpha-glutamyl tryptophan, gamma glutamyl tryptophan and alpha-lysyl glutamine. The composition also comprises a co-inducer of endogenous interferon - glycyrrhizic acid, taken in the form of a sodium salt or ammonium salt in an amount of 50 - 500 mg per dose.

  本发明涉及药物，特别是以肽为基础的药物制剂。该组合物包括每治疗剂量 0.01 - 0.03 毫克的内源性干扰素诱导剂--谷氨酸二肽，该二肽选自α-谷氨酰色氨酸、γ-谷氨酰色氨酸和α-赖氨酰谷氨酰胺组成的组。该组合物还包括内源性干扰素的辅助诱导剂--甘草酸，以钠盐或铵盐的形式服用，每次剂量为 50-500 毫克。