methyl 2-[[2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]acetate | 78758-92-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-[[2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]acetate
• CAS: 78758-92-6
• 化学式: C₁₆H₂₀N₄O₄
• 分子量: 332.359
• InChiKey: VKAGIRKNEXPUSZ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl [[(2S)-3-(1H-indol-3-yl)-2-(t-butoxycarbonylamino)propanoylamino]acetylamino]acetate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 methyl 2-[[2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]acetate
  参考文献：
  名称：

  Amino acid derivatives, IX [1]: synthesis and antimicrobial evaluation of α-amino acid esters bearing a tryptophane side chain

  摘要：

  A series of peptide and dipeptide derivatives conjugated with a tryptophane residue were synthesized. The prepared compounds were tested for antimicrobial activity against four different bacterial species displaying different degrees of antibacterial activities or inhibitory actions.

  DOI：

  10.1007/s00706-008-0952-y

文献信息

• Amino acid derivatives, IX [1]: synthesis and antimicrobial evaluation of α-amino acid esters bearing a tryptophane side chain
  作者：Ahmed Hameurlaine、Wael A. El-Sayed、Adel A.-H. Abdel-Rahman

  DOI：10.1007/s00706-008-0952-y

  日期：2008.12

  A series of peptide and dipeptide derivatives conjugated with a tryptophane residue were synthesized. The prepared compounds were tested for antimicrobial activity against four different bacterial species displaying different degrees of antibacterial activities or inhibitory actions.