Carbamic acid, [3-[(3-aminopropyl)amino]propyl]- | 868362-45-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Carbamic acid, [3-[(3-aminopropyl)amino]propyl]-
• 英文别名: 3-(3-aminopropylamino)propylcarbamic acid
• CAS: 868362-45-2
• 化学式: C₇H₁₇N₃O₂
• 分子量: 175.23
• InChiKey: WKWWVRMILPQYHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• KINASE MODULATORS FOR THE TREATMENT OF CANCER
  申请人：Synovo GmbH

  公开号：US20170313661A1

  公开（公告）日：2017-11-02

  A method of treating cancer in which a compound that inhibits the expression, production or release of IL-10 by immune cells is combined with a compound that stimulates the production of IL-12 when given in combination with, or in the presence of TNFa. Said method is effective when provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.

  一种治疗癌症的方法，其中抑制免疫细胞表达、产生或释放IL-10的化合物与在与TNFa联合给予或存在的情况下刺激IL-12产生的化合物结合。所述方法在提供标准疗法的基础上有效，特别是包括使用细胞毒性药物的化疗和其他形式的免疫疗法，包括治疗性疫苗。
• COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20150038512A1

  公开（公告）日：2015-02-05

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明涉及一种包含聚胺化合物的化合物、组合物和方法，可用于杀死、分散、治疗或减少生物膜，或抑制或大幅预防生物膜的形成。在某些方面，本发明涉及包含聚胺化合物的化合物、组合物和方法，其具有针对能够形成生物膜的各种细菌菌株的抗微生物或分散活性。
• Methods comprising a biocidal polyamine
  申请人：Curza Global, LLC

  公开号：US10440955B2

  公开（公告）日：2019-10-15

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明描述了包含多胺化合物的化合物、组合物和方法，这些化合物、组合物和方法可用于杀灭、分散、处理或减少生物膜，或用于抑制或基本防止生物膜的形成。在某些方面，本发明涉及包含多胺化合物的化合物、组合物和方法，这些化合物对能够形成生物膜的各种细菌菌株具有抗菌或分散活性。
• COMPOSITIONS AND METHODS COMPRISING A POLYAMINE
  申请人：Curza Global LLC

  公开号：EP2999345A1

  公开（公告）日：2016-03-30
• COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20160330962A1

  公开（公告）日：2016-11-17

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.