丁酸壬酯 | 2639-64-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丁酸壬酯
• 英文名称: Nonylbutyrat
• 英文别名: Nonyl butyrate；nonyl butanoate
• CAS: 2639-64-7
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.348
• InChiKey: RVNCBAPCNVAWOY-UHFFFAOYSA-N

物化性质

• 熔点：
  -51°C (estimate)
• 沸点：
  261.85°C
• 密度：
  0.8586
• LogP：
  5.371 (est)
• 保留指数：
  1461;1463;1464;1466;1489;1471;1470;1470

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• [EN] PROCESSES FOR PRODUCING CARBOXYLIC ACIDS<br/>[FR] PROCÉDÉS DE PRODUCTION D'ACIDES CARBOXYLIQUES
  申请人：EASTMAN CHEM CO

  公开号：WO2020205348A1

  公开（公告）日：2020-10-08

  Processes are disclosed for preparing carboxylic acids from organic esters, the processes comprising contacting an ester with water in the presence of an acid catalyst and a homogenizing solvent at conditions effective to form a carboxylic acid. The homogenizing solvent is present in an amount sufficient to form a single-phase reaction mixture comprising the ester, water, and homogenizing solvent. The homogenizing solvent may be selected from acetonitrile, dimethyl sulfoxide, and 1,4-dioxane.

  公开了从有机酯制备羧酸的过程，该过程包括在酸催化剂和均相溶剂存在下将酯与水接触，以形成羧酸的有效条件。均相溶剂以足够量存在，以形成包括酯、水和均相溶剂的单相反应混合物。均相溶剂可以选择自乙腈、二甲基亚砜和1,4-二氧六环。
• TRANSESTERIFICATION PROCESS USING MIXED SALT ACETYLACETONATES CATALYSTS
  申请人：Goossens Thomas Peter Anne

  公开号：US20130090492A1

  公开（公告）日：2013-04-11

  This invention is directed to a general catalyst of high activity and selectivity for the production of a variety of esters, particularly acrylate and methacrylate-based esters, by a transesterification reaction. This objective is achieved by reaction of an ester of a carboxylic or a carbonic acid, in particular of a saturated or unsaturated, typically, a 3 to 4 carbon atom carboxylic acid; with an alcohol in the presence of a catalyst comprising the combination of a metal 1,3-dicarbonyl complex (pref. Zn or Fe acetylacetonate) and a salt, in particular an inorganic salt, pref. ZnCl2, LiCI, NaCI, NH4CI or Lil. These catalysts are prepared from readily available starting materials within the reaction medium without the need for isolation (in-situ preparation).

  这项发明针对一种高活性和选择性的通用催化剂，用于通过酯交换反应生产各种酯类，特别是丙烯酸酯和甲基丙烯酸酯。该目标通过在存在催化剂的情况下，将羧酸酯或碳酸酯的酯，特别是饱和或不饱和的、通常为3到4个碳原子的羧酸酯；与醇反应来实现。催化剂包括金属1,3-二羰基配合物（首选Zn或Fe乙酰丙酮酸盐）和盐的组合，特别是无机盐，首选ZnCl2，LiCl，NaCl，NH4Cl或I2。这些催化剂是在反应介质中从易得的起始物质制备而成，无需分离（原位制备）。
• Lewis acid catalyst composition
  申请人：——

  公开号：US20040242411A1

  公开（公告）日：2004-12-02

  A Lewis acid catalyst composition comprising a specific mixed medium and a Lewis acid catalyst, wherein the Lewis acid catalyst is at least one compound selected from the group consisting of compounds respectively represented by the following formulae (1) and (2): [(R f 1 SO 2 )(R f 2 SO 2 )N] n M  (1), and [(R f 1 SO 2 )(R f 2 SO 2 )(R f 3 SO 2 )C] n M  (2). A method for continuously performing a reaction which proceeds in the presence of the above-mentioned Lewis acid catalyst by using a specific mixed medium and the above-mentioned Lewis acid catalyst. A novel Lewis acid catalyst.

  一种Lewis酸催化剂组合物，包括特定混合介质和Lewis酸催化剂，其中Lewis酸催化剂是从以下式(1)和(2)所代表的化合物组成的化合物中至少选择一种：[(Rf1SO2)(Rf2SO2)N]nM  (1)，以及[(Rf1SO2)(Rf2SO2)(Rf3SO2)C]nM  (2)。一种使用特定混合介质和上述Lewis酸催化剂连续进行反应的方法。一种新型Lewis酸催化剂。
• A method for improving the release of a cast concrete item from the mould by applying to the mould a mould release composition
  申请人：CASTROL A/S

  公开号：EP0328158A1

  公开（公告）日：1989-08-16

  The release of a moulded concrete body from the mould can be improved by applying to the mould an effective amount of a concrete release composition comprising one or more oily esters of aliphatic carboxylic acids with mono- or dihydric alcohols, with a melting point of at the most 35°C, the total number of carbon atoms in the esters being 8-46, in an amount of 26-100% by weight, calculated on the total composition, optionally in admixture with other additives such as mineral oils, vegetable oils, glycols, glycol ethers, alkanols, emulsifiers and/or water.

  在模具上涂抹有效量的混凝土脱模组合物，可改善模制混凝土体的脱模效果，该组合物由一种或多种脂肪族羧酸与一元醇或二元醇的油性酯组成，熔点不超过 35°C、酯中的碳原子总数为 8-46，重量百分比为 26-100%，以总成分计算，可与其他添加剂如矿物油、植物油、乙二醇、乙二醇醚、烷醇、乳化剂和/或水混合使用。

表征谱图