{[2-(acetyloxy)benzoyl]oxy}methyl 6-[(nitrooxy)methyl]pyridine-2-carboxylate | 1144618-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {[2-(acetyloxy)benzoyl]oxy}methyl 6-[(nitrooxy)methyl]pyridine-2-carboxylate
• 英文别名: (2-acetyloxybenzoyl)oxymethyl 6-(nitrooxymethyl)pyridine-2-carboxylate
• CAS: 1144618-73-4
• 化学式: C₁₇H₁₄N₂O₉
• 分子量: 390.306
• InChiKey: TVMZXNLIRNHHPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  147
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  {[2-(acetyloxy)benzoyl]oxy}methyl 6-(hydroxymethyl)pyridine-2-carboxylate 在 硝酸 作用下， 以 乙酸酐 为溶剂， 反应 2.0h， 以50%的产率得到{[2-(acetyloxy)benzoyl]oxy}methyl 6-[(nitrooxy)methyl]pyridine-2-carboxylate
  参考文献：
  名称：

  [EN] NEW NO-DONOR ASPIRIN DERIVATIVES
  [FR] NOUVEAUX DÉRIVÉS D'ASPIRINE DONNEURS NO

  摘要：

  公开号：

  WO2009049961A3

文献信息

• NEW NO-DONOR ASPIRIN DERIVATIVES
  申请人：Fruttero Roberta

  公开号：US20100210694A1

  公开（公告）日：2010-08-19

  The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.

  本发明涉及一种新的NO供体阿司匹林衍生物，其制备方法和包含它们的药物组合物。
• [EN] NEW NO-DONOR ASPIRIN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'ASPIRINE DONNEURS NO
  申请人：NICOX SA

  公开号：WO2009049961A3

  公开（公告）日：2009-06-25
• (Nitrooxyacyloxy)methyl Esters of Aspirin as Novel Nitric Oxide Releasing Aspirins
  作者：Loretta Lazzarato、Monica Donnola、Barbara Rolando、Konstantin Chegaev、Elisabetta Marini、Clara Cena、Antonella Di Stilo、Roberta Fruttero、Stefano Biondi、Ennio Ongini、Alberto Gasco

  DOI：10.1021/jm900587h

  日期：2009.8.27

  A series of (nitrooxyacyloxy)methyl esters of aspirin were synthesized and evaluated as new NO-donor aspirins. Different amounts of aspirin were released in serum from these products according to the nature of nitrooxyacyloxy moiety present, In the aromatic series, there is a rather good linear correlation between the amount of aspirin released and the potencies of the products in inhibiting platelet aggregation induced by collagen. Both the native compounds and the related nitrooxy-substituted acid metabolites were able to relax rat aorta strips precontracted with phenylephrine, in keeping with a NO-induced activation or the sGC as a mechanism that underlies the vasodilator effect. The products here described are new improved examples of NO-donor aspirins containing nitrooxy groups. They could represent all alternative to the use of aspirin ill a variety of clinical applications.