3-(2H,3H-Benzo[3,4-E]1,4-dioxan-6-YL)(3S)-3-aminopropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2H,3H-Benzo[3,4-E]1,4-dioxan-6-YL)(3S)-3-aminopropanoic acid
• 英文别名: (3S)-3-amino-3-(2,3-dihydro-1,4-benzodioxin-6-yl)propanoic acid
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.22
• InChiKey: CAGUEQZBLIGCEU-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  86.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1183241A1

  公开（公告）日：2002-03-06
• US6399643B1
  申请人：——

  公开号：US6399643B1

  公开（公告）日：2002-06-04
• [EN] SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM<br/>[FR] DERIVES DE SPIROIMIDAZOLIDINE, PREPARATION ET UTILISATION DE CES DERIVES ET PREPARATION PHARMACEUTIQUES A BASE DE CES DERIVES.
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2000069831A1

  公开（公告）日：2000-11-23

  The present invention relates to spiroimidazolidine derivatives of formula (I) in which E, V, W, X, R?1 and R2¿ have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of formula (I) are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy and prophylaxis of illnesses which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of formula (I), their use and pharmaceutical preparations which contain compounds of formula (I).