ethyl 3-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: ethyl 3-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate
• 英文别名: Ethyl 3-bromo-8-methylimidazo [1,2-a]pyridine-2-carboxylate
• 化学式: C₁₁H₁₁BrN₂O₂
• 分子量: 283.125
• InChiKey: ACCKJGJUCOKRPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-3-甲基吡啶 、 3-溴丙酮酸乙酯 在 二甲基亚砜 作用下， 反应 0.17h， 以70%的产率得到ethyl 3-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate
  参考文献：
  名称：

  Microwave-Assisted One-Pot Synthesis of Substituted 3-Bromoimidazo[1,2-a]pyridines and Imidazoheterocycles

  摘要：

  Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo[1,2‐a]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation

  DOI：

  10.1002/jhet.1764

文献信息

• Microwave-Assisted One-Pot Synthesis of Substituted 3-Bromoimidazo[1,2-<i><b>a</b></i>]pyridines and Imidazoheterocycles
  作者：Shashikant M. Patil、Malcolm Mascarenhas、Rajiv Sharma、S. Mohana Roopan、Abhijit Roychowdhury

  DOI：10.1002/jhet.1764

  日期：2014.9

  Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo[1,2‐a]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation