(+)-ethyl 4-propargyl-2-phenylthiazoline-4-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+)-ethyl 4-propargyl-2-phenylthiazoline-4-carboxylate
• 英文别名: ethyl 2-phenyl-4-prop-2-ynyl-5H-1,3-thiazole-4-carboxylate
• 化学式: C₁₅H₁₅NO₂S
• 分子量: 273.356
• InChiKey: ACVXYQDNVBYYGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Ethyl 5,5-dihydro-2-phenyl-2-thiazoline-4-carboxylate 、 3-溴丙炔 生成 (+)-ethyl 4-propargyl-2-phenylthiazoline-4-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Process for producing optically active alpha-substituted cysteine or salt thereof, intermediate therefor, and process for producing the same
  申请人：Maruoka Keiji

  公开号：US20060069134A1

  公开（公告）日：2006-03-30

  The present invention provides a simple, practical, and industrially advantageous process for producing an optically active α-substituted cysteine or a salt thereof from inexpensive and readily available materials. The present invention provides a process for producing an optically active α-substituted cysteine or a salt thereof by converting a cysteine derivative into a thiazoline compound and subjecting the resulting thiazoline compound to a stereoselective substituent-introducing reaction catalyzed by an optically active quaternary ammonium salt, in particular, an axially asymmetric quaternary ammonium salt to produce an optically active thiazoline compound and then hydrolyzing the resulting thiazoline compound.

  本发明提供一种简单、实用且具有工业优势的工艺，从廉价且易得的材料中生产出光学活性的α-取代半胱氨酸或其盐。本发明提供了一种生产光学活性α-取代半胱氨酸或其盐的工艺，通过将半胱氨酸衍生物转化为噻唑环化合物，并将所得的噻唑环化合物在光学活性季铵盐的催化下进行立体选择性取代基引入反应，特别是在轴向不对称季铵盐的催化下，产生光学活性噻唑环化合物，然后水解所得的噻唑环化合物。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE ALPHA-SUBSTITUTED CYSTEINE OR SALT THEREOF, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING THE SAME
  申请人：KANEKA CORPORATION

  公开号：EP1548013A1

  公开（公告）日：2005-06-29

  The present invention provides a simple, practical, and industrially advantageous process for producing an optically active α-substituted cysteine or a salt thereof from inexpensive and readily available materials. The present invention provides a process for producing an optically active α-substituted cysteine or a salt thereof by converting a cysteine derivative into a thiazoline compound and subjecting the resulting thiazoline compound to a stereoselective substituent-introducing reaction catalyzed by an optically active quaternary ammonium salt, in particular, an axially asymmetric quaternary ammonium salt to produce an optically active thiazoline compound and then hydrolyzing the resulting thiazoline compound.

  本发明提供了一种利用廉价易得材料生产光学活性α-取代半胱氨酸或其盐的简单、实用和具有工业优势的工艺。 本发明提供了一种生产光学活性α-取代半胱氨酸或其盐的工艺，其方法是将半胱氨酸衍生物转化为噻唑啉化合物，并使所得噻唑啉化合物在光学活性季铵盐，特别是轴向不对称季铵盐催化下进行立体选择性取代基引入反应，生成光学活性噻唑啉化合物，然后水解所得噻唑啉化合物。