3-(3-phenoxybenzenesulfonyl)-1-phenyl-imidazolidin-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(3-phenoxybenzenesulfonyl)-1-phenyl-imidazolidin-2,4-dione
• 英文别名: 3-(3-Phenoxy-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dione；3-(3-phenoxyphenyl)sulfonyl-1-phenylimidazolidine-2,4-dione
• 化学式: C₂₁H₁₆N₂O₅S
• 分子量: 408.434
• InChiKey: ADZFNVIOXMBWIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  92.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-苯基甘氨酸 在 氯甲酸乙酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 生成 3-(3-phenoxybenzenesulfonyl)-1-phenyl-imidazolidin-2,4-dione
  参考文献：
  名称：

  Substituted 3-(Phenylsulfonyl)-1-phenylimidazolidine-2,4-dione Derivatives as Novel Nonpeptide Inhibitors of Human Heart Chymase

  摘要：

  A series of 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives have been synthesized and evaluated for their ability to selectively inhibit human heart chymase. The structure-activity relationship studies on these compounds gave the following results. The 1-phenyl moiety participates in a hydrophobic interaction where an optimum size is required. At this position, 3,4-dimethylphenyl is the best moiety for inhibiting chymase and showed high selectivity compared with chymotrypsin and cathepsin G. A 3-phenylsulfonyl moiety substituted with hydrogen-bond accepters such as nitrile and methoxycarbonyl enhances its activity. Molecular-modeling studies on the interaction of 3-[(4-chlorophenyl)sulfonyl]-1-(4-chlorophenyl)imidazolidine-2,4-dione (29) with the active site of human heart chymase suggested that the 1-phenyl moiety interacts with the hydrophobic P-1 pocket, the 3-phenylsulfonyl moiety resides in the S-1'-S-2' subsites, and the 4-carbonyl of the imidazolidine ring and sulfonyl group interact with the oxyanion hole and the His-45 side chain of chymase, respectively. The complex model is consistent with the structure-activity relationships.

  DOI：

  10.1021/jm960793t

文献信息

• Imidazolidine derivative and use thereof
  申请人：Suntory Limited

  公开号：US05691335A1

  公开（公告）日：1997-11-25

  The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C.sub.1-4 alkyl groups, C.sub.1-4 alkoxy groups, C.sub.1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C.sub.2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.

  该发明涉及一种由以下一般式（1）表示的咪唑啉衍生物：##STR1##其中A和B分别表示芳香烃基，该基可能被1-3个卤原子、C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷二氧基、苯氧基、硝基、氰基、苯基、C.sub.2-5烷酰氨基、可能与C.sub.1-4烷基或烯基酯化的羧基、可能与C.sub.1-4烷基或烯基酯化的羧基烷基、可能与C.sub.1-4烷基或烯基酯化的羧基烷氧基、N-烷基哌嗪甲酰基、N-烷基哌嗪甲酰基烷基、N-烷基哌嗪甲酰基烷氧基和吗啉甲酰基；X表示磺酰基或羰基；Y代表氧原子或硫原子，包括作为活性成分的Ⅰ型肽酶抑制剂、以及作为活性成分的药物，其为一种心脏或循环系统疾病的预防和治疗剂，该疾病是由于抑制Ⅱ型肽酶的异常加速产生而引起的。
• IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
  申请人：SUNTORY LIMITED

  公开号：EP0721944B1

  公开（公告）日：2001-01-17
• US5691335A
  申请人：——

  公开号：US5691335A

  公开（公告）日：1997-11-25
• Substituted 3-(Phenylsulfonyl)-1-phenylimidazolidine-2,4-dione Derivatives as Novel Nonpeptide Inhibitors of Human Heart Chymase
  作者：Shinjiro Niwata、Harukazu Fukami、Motoo Sumida、Akiko Ito、Saki Kakutani、Masayuki Saitoh、Kenji Suzuki、Masahiro Imoto、Hiroshi Shibata、Seiichi Imajo、Yoshinobu Kiso、Takaharu Tanaka、Hiroshi Nakazato、Takafumi Ishihara、Shinji Takai、Daisuke Yamamoto、Naotaka Shiota、Mizuo Miyazaki、Hideki Okunishi、Akio Kinoshita、Hidenori Urata、Kikuo Arakawa

  DOI：10.1021/jm960793t

  日期：1997.7.1

  A series of 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives have been synthesized and evaluated for their ability to selectively inhibit human heart chymase. The structure-activity relationship studies on these compounds gave the following results. The 1-phenyl moiety participates in a hydrophobic interaction where an optimum size is required. At this position, 3,4-dimethylphenyl is the best moiety for inhibiting chymase and showed high selectivity compared with chymotrypsin and cathepsin G. A 3-phenylsulfonyl moiety substituted with hydrogen-bond accepters such as nitrile and methoxycarbonyl enhances its activity. Molecular-modeling studies on the interaction of 3-[(4-chlorophenyl)sulfonyl]-1-(4-chlorophenyl)imidazolidine-2,4-dione (29) with the active site of human heart chymase suggested that the 1-phenyl moiety interacts with the hydrophobic P-1 pocket, the 3-phenylsulfonyl moiety resides in the S-1'-S-2' subsites, and the 4-carbonyl of the imidazolidine ring and sulfonyl group interact with the oxyanion hole and the His-45 side chain of chymase, respectively. The complex model is consistent with the structure-activity relationships.