Study of Synthesis and Cardiovascular Activity of Some Furoxan Derivatives as Potential NO-Donors.
作者:Li MU、Si-shen FENG、Mei Lin GO
DOI:10.1248/cpb.48.808
日期:——
contraction by more than 30% at 10 microM. All except one of these compounds are characterized by the presence of electron withdrawing groups in the phenyl ring attached via an amide or ester linkage to the furoxan moiety. The nature of the terminal carbonyl linkage (ester or amide) and the length or type of the alkyl chain bridging the two carbonyl functions have little effect on the activity. One of the active