acetoxy-benzoyloxy-methane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetoxy-benzoyloxy-methane
• 英文别名: Methylenglykol-acetat-benzoat；Acetoxy-benzoyloxy-methan；Acetyloxymethyl benzoate
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: AENSJQSUTSFKEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲酸氯甲基 在 potassium acetate 作用下， 生成 acetoxy-benzoyloxy-methane
  参考文献：
  名称：

  Descude, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1902, vol. 134, p. 717

  摘要：

  DOI：

文献信息

• Palladium(II)-Catalyzed<i>ortho</i>Alkylation of Benzoic Acids with Alkyl Halides
  作者：Yang-Hui Zhang、Bing-Feng Shi、Jin-Quan Yu

  DOI：10.1002/anie.200902262

  日期：2009.8.3

  Outsmarting the competition: In the PdII‐catalyzed reaction of benzoates with alkyl halides, an aryl CH bond is activated before the competitive alkylation of the carboxylate anion can takes place. The alkylation reaction was followed by an intramolecular lactonization to give broadly useful γ‐ and δ‐benzolactones (see scheme).

  战胜竞争：在 Pd II催化的苯甲酸盐与卤代烷的反应中，芳基 C  H 键在羧酸根阴离子的竞争性烷基化发生之前被激活。烷基化反应后进行分子内内酯化，得到广泛有用的 γ- 和 δ-苯内酯（参见方案）。
• ANTIHYPERTENSIVE POLYOL COMPOUND AND DERIVATIVE THEREOF
  申请人：East China University of Science and Technology

  公开号：EP3906969A1

  公开（公告）日：2021-11-10

  The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

  本发明提供了一种由式I代表的化合物，或其药用可接受的盐或酯，前药，光学异构体，立体异构体或其溶剂合物。本发明提供的化合物可用于制备用于预防或治疗高血压或与高血压相关疾病，或肺动脉高压或与肺动脉高压相关疾病的药物。本发明提供的化合物与现有用于治疗高血压和肺动脉高压的药物具有不同的机制，从而为开发用于治疗高血压和肺动脉高压的药物奠定了新的物质基础。
• [EN] AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS<br/>[FR] DERIVES D'AMINONICOTINATE JOUANT LE ROLE DE MODULATEURS DE GLUCOKINASE (GLK)
  申请人：ASTRAZENECA AB

  公开号：WO2003000267A1

  公开（公告）日：2003-01-03

  The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R?1?, R2, R3, n and m are as described in the specification, useful in the treatment of a (A chemical formula should be inserted here - please see paper copy enclosed) Formula (I) disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

  本发明涉及一种新型化合物的公式（I）或其盐，溶剂化物或前药，其中R?1？，R2，R3，n和m如规范中所述，对治疗通过葡萄糖激酶（GLK）介导的（这里应插入一种化学式-请参见随附的纸质副本）公式（I）疾病或病况有用，例如2型糖尿病。本发明还涉及制备公式（I）化合物的方法及其作为治疗由葡萄糖激酶介导的疾病的药物的用途。
• Amino nicotinate derivatives as glucokinase (GLK) modulators
  申请人：——

  公开号：US20040214868A1

  公开（公告）日：2004-10-28

  The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, useful in the treatment of a 1 disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

  该发明涉及式（I）的新化合物或其盐，溶剂化合物或前药，其中R1，R2，R3，n和m如规范所述，在通过葡萄糖激酶（GLK）介导的疾病或症状的治疗中有用，例如2型糖尿病。该发明还涉及制备式（I）化合物的方法，以及它们作为药物治疗由葡萄糖激酶介导的疾病的用途。
• Method for producing (hydroxyalkyl)alicyclic carboxylic acids and intermediates therefor
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1043304A1

  公开（公告）日：2000-10-11

  (Acyloxyalkyl)aromatic carboxylic acids are produced by partial oxidation of an alkyl-substituted aromatic compound of the general formula         CHR1R2 - Ar - (R3)n     (1)    in which Ar is an aromatic ring; R1 is H or alkyl having 1 to 3 carbon atoms; R2 is H, alkyl having 1 to 3 carbon atoms or -OCOR5; R3 is alkyl having 1 to 4 carbon atoms, -COOH, -CHO, -CH2R4 or -COOR5; n is an integer from 1 to 5; R4 is halogen, -OH or -OCOR5; and R5 is alkyl having 1 to 4 carbon atoms, and a carboxylic acid in the presence of oxygen and a catalyst including an element of Group VIII of the Periodic Table. (Hydroxyalkyl)alicyclic carboxylic acids are produced by hydrolysis/hydrogenation or hydrogenation/hydrolysis of the (acyloxyalkyl) aromatic carboxylic acids.

  (酰氧基烷基)芳香族羧酸是通过部分氧化通式如下的烷基取代的芳香族化合物制得的 CHR1R2 - Ar - (R3)n (1) 其中 Ar 是芳香环；R1 是 H 或具有 1 至 3 个碳原子的烷基；R2 是 H、具有 1 至 3 个碳原子的烷基或 -OCOR5；R3 是具有 1 至 4 个碳原子的烷基、-COOH、-CHO、-CH2R4 或 -COOR5；n 是 1 至 5 的整数；R4 是卤素、-OH 或 -OCOR5；R5 是具有 1 至 4 个碳原子的烷基，以及一种羧酸，在氧和包括元素周期表第八族元素的催化剂存在下进行部分氧化。(羟烷基)脂环族羧酸是通过(酰氧基烷基)芳香族羧酸的水解/加氢或氢化/水解制得的。