methyl 2-(2-hydroxybenzyl)-3-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: methyl 2-(2-hydroxybenzyl)-3-oxobutanoate
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: AFLWVRDJBVJPOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.31
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  水杨醇 、 乙酰乙酸甲酯 在 rice husk ash nano silica supported 12-tungstophosphoric acid 作用下， 反应 0.08h， 以95%的产率得到methyl 2-(2-hydroxybenzyl)-3-oxobutanoate
  参考文献：
  名称：

  稻壳灰中负载在纳米二氧化硅上的12-钨磷酸作为无溶剂条件下1,3-二羰基化合物直接苄基化的有效催化剂

  摘要：

  纳米二氧化硅是由稻壳制成的，稻壳是一种农业废料，具有高表面积和无定形形式。在该二氧化硅上负载有12钨磷酸H 3 PW 12 O 40（PW），以生产作为纳米催化剂的纳米二氧化硅负载的PW（NPW / SiO 2）。通过TEM，FTIR和ICP对这种催化剂的表征进行了研究，并且通过电位滴定法对酸性进行了研究。40％NPW /二氧化硅2已被用作高效的催化剂，用于用苄醇对1，3-二羰基化合物进行苄基化。本方法提供了在无溶剂条件下的清洁，实用，简单，温和，环保，绿色且省时的方法。同样，该催化剂是大规模用于1，3-二羰基化合物的直接苄基化的良好选择。

  DOI：

  10.1016/j.molcata.2011.10.008

文献信息

• Direct benzylation of 1,3-dicarbonyl compounds catalyzed by Cs_2.5H_0.5PW₁₂O₄₀ in solvent-free conditions
  作者：Ezzat Rafiee、Maryam Khodayari、Mohammad Joshaghani

  DOI：10.1139/v11-134

  日期：2011.12

  improved modification of the direct benzylation of 1,3-carbonyl compounds in terms of low reaction times, solvent-free conditions, usage of a small amount of the catalyst, and a clean reaction profile. Furthermore, the use of this catalyst is feasible because of its easy preparation, its easy handling, its stability, its easy recovery, its reusability, being environmentally green, its excellent activity

  在 Cs2.5H0.5PW12O40 盐的存在下，各种 1,3-二羰基化合物很容易与苄醇反应，以高产率生成 2-苄基-1,3-二羰基化合物。发现这种催化剂可以完全回收和再利用而不会损失其催化活性，因此具有环保意识，尤其是在无溶剂条件下。在低反应时间、无溶剂条件、使用少量催化剂和干净的反应曲线方面，该方法的使用提供了对 1,3-羰基化合物的直接苄基化的改进改进。此外，这种催化剂的使用是可行的，因为它易于制备、易于处理、稳定性、易于回收、可重复使用、环境绿色、活性优良、选择性好。
• CURABLE POLYESTERS AND THERMOSETTING COMPOSTIONS CONTAINING RESOLE PHENOLIC RESINS
  申请人：Eastman Chemical Company

  公开号：US20160115345A1

  公开（公告）日：2016-04-28

  There is now provided a variety of curable polyester resins that cure well with phenolic crosslinking agents. The curable polyester resins include polyester resins that have both carboxyl and hydroxyl functionalities and a high ratio of carboxyl functionalities to hydroxyl functionalities; unsaturated curable polyester having residues of an α,β-unsaturated polycarboxylic acid compound with at least one unsaturation in a position that is α,β relative to a carbonyl group and not located on an aromatic ring; and a curable polyester resin containing beta-ketoacetate moieties without vinyl unsaturation. The curable polyester resin can be dispersed in water or dissolved in a solvent and is suitable for waterborne or solventborne coating compositions. Phenolic based crosslinking coating compositions that contain these curable polyester resins cure well with phenolic resin crosslinking compounds with a wide variety of reactive curable polyester resins or other kinds of polyester resins.
• THERMOSETTING COMPOSITIONS BASED ON PHENOLIC RESINS AND CURABLE POLEYESTER RESINS MADE WITH DIKETENE OR BETA-KETOACETATE CONTAINING COMPOUNDS
  申请人：Eastman Chemical Company

  公开号：US20160137877A1

  公开（公告）日：2016-05-19

  A thermosetting composition having: I. a curable polyester resin containing beta-ketoacetate moieties without vinyl unsaturations; and II. a phenolic resin having at least one methylol group. The curable polyester resin can be made by reacting a polyester resin with a compound containing a beta-ketoacetate moiety that does not contain a vinyl unsaturation such as alkyl acetoacetate compounds or diketene compounds. The curable polyester resin can be dispersed in water or dissolved in a solvent and is suitable for waterborne or solventborne coating compositions. Phenolic based crosslinking coating compositions that contain these curable polyester resins cure well with phenolic resin crosslinking compounds.
• US9598602B2
  申请人：——

  公开号：US9598602B2

  公开（公告）日：2017-03-21