methyl N-[4-(2-hydroxy-3-piperidinopropoxy)phenyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl N-[4-(2-hydroxy-3-piperidinopropoxy)phenyl]carbamate
• 英文别名: methyl-N-[4-(2-hydroxy-3-piperidinopropoxy)phenyl]-carbamate；methyl N-[4-(2-hydroxy-3-piperidin-1-ylpropoxy)phenyl]carbamate
• 化学式: C₁₆H₂₄N₂O₄
• 分子量: 308.378
• InChiKey: AGRMTDGOCXUWBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  71
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl N-(4-hydroxyphenyl)carbamate 在 potassium carbonate 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 反应 11.0h， 生成 methyl N-[4-(2-hydroxy-3-piperidinopropoxy)phenyl]carbamate
  参考文献：
  名称：

  Synthesis of Methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates

  摘要：

  By alkylation of methyl-N-(4-hydroxyphenyl) carbamate with (chloroniethyl)oxirane in acetone in the presence of K2CO3 methyl-N-[4-(2,3-epoxypropoxy)phenyl]carbamate was prepared. The aminolysis of the latter effected by benzylamine, morpholine, piperidine, and pyrrolidine occurs in keeping with Krasusky rule to afford methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates.

  DOI：

  10.1023/b:rujo.0000034939.01295.42

文献信息

• Synthesis of Methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates
  作者：A. V. Velikorodov

  DOI：10.1023/b:rujo.0000034939.01295.42

  日期：2004.2

  By alkylation of methyl-N-(4-hydroxyphenyl) carbamate with (chloroniethyl)oxirane in acetone in the presence of K2CO3 methyl-N-[4-(2,3-epoxypropoxy)phenyl]carbamate was prepared. The aminolysis of the latter effected by benzylamine, morpholine, piperidine, and pyrrolidine occurs in keeping with Krasusky rule to afford methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates.