西诺呋隆 | 477-80-5

• 分子结构分类: 有机化合物 - 苯类化合物
• 中文名称: 西诺呋隆
• 中文别名: 辛呋二酮；二苯吡嗪唑酮
• 英文名称: 2-tetrahydrofurfuryl-benzo[c]pyrazolo[1,2-a]cinnoline-1,3-dione
• 英文别名: 2-Tetrahydrofurfuryl-benzo[c]pyrazolo[1,2-a]cinnolin-1,3-dion；Cinnofuradione；4-(oxolan-2-ylmethyl)-2,6-diazatetracyclo[11.4.0.02,6.07,12]heptadeca-1(17),7,9,11,13,15-hexaene-3,5-dione
• CAS: 477-80-5
• 化学式: C₂₀H₁₈N₂O₃
• 分子量: 334.375
• InChiKey: MTRUDCIZADOOBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯并[c]噌啉 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium ethanolate 、 铂 作用下， 生成 西诺呋隆
  参考文献：
  名称：

  New 5:6-dihydro-benzo (c) cinnoline derivatives and a process for their preparation

  摘要：

  公开号：

  US02778829A1

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• POLYMERIZATION INITIATOR, CURABLE COMPOSITION, DENTAL MATERIAL, AND PREPARATION KIT FOR CURABLE COMPOSITION
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3835329A1

  公开（公告）日：2021-06-16

  Provided is a polymerization initiator, which has an excellent curing rate and is an alternative to a polymerization initiator system using a benzoyl peroxide-aromatic amine compound, a curable composition containing the polymerization initiator, a dental material and dental filler material containing the composition, and a kit for preparing the curable composition. The present invention includes a polymerization initiator containing one or more compounds (A) selected from the group consisting of a pyrazolidinedione compound and/or pyrazolidine(di)thione compound (A1), a salt (A2) of the compound (A1), and a malonate compound (A3).

  本发明提供了一种聚合引发剂，它具有优异的固化率，可替代使用过氧化苯甲酰-芳香胺化合物的聚合引发剂体系；还提供了一种含有该聚合引发剂的可固化组合物、一种含有该组合物的牙科材料和牙科填充材料，以及一种用于制备该可固化组合物的试剂盒。 本发明包括一种聚合引发剂，其中含有一种或多种选自由吡唑烷二酮化合物和/或吡唑烷（二）硫酮化合物（A1）、化合物（A1）的盐（A2）和丙二酸酯化合物（A3）组成的组的化合物（A）。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY
  申请人：Scidose, Llc

  公开号：EP1954244A1

  公开（公告）日：2008-08-13
• CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION
  申请人：STI Pharma, LLC

  公开号：EP2717860A1

  公开（公告）日：2014-04-16