benzyl-(2,6-dichlorobenzyl)-methylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl-(2,6-dichlorobenzyl)-methylamine
• 英文别名: N-[(2,6-dichlorophenyl)methyl]-N-methyl-1-phenylmethanamine
• 化学式: C₁₅H₁₅Cl₂N
• 分子量: 280.197
• InChiKey: AHTLZTVHMPWMMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基苄胺 、 2,6-二氯苄基溴 在 triazolylmethyl acrylate resin 、 TEA 作用下， 以 N,N-二甲基甲酰胺 、 二甲基亚砜 为溶剂， 反应 38.0h， 以68%的产率得到benzyl-(2,6-dichlorobenzyl)-methylamine
  参考文献：
  名称：

  Click chemistry on solid support: synthesis of a new REM resin and application for the preparation of tertiary amines

  摘要：

  1,3-Dipolar cycloaddition was employed for the synthesis of a highly practical REM resin. Exploiting this concept, the resulting triazolylmethyl acrylate (TMA) resin was used for an efficient parallel synthesis of tertiary amines by Michael addition, subsequent quarternization and cleavage by means of beta-elimination. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.099

文献信息

• Click chemistry on solid support: synthesis of a new REM resin and application for the preparation of tertiary amines
  作者：Stefan Löber、Peter Gmeiner

  DOI：10.1016/j.tet.2004.05.099

  日期：2004.9

  1,3-Dipolar cycloaddition was employed for the synthesis of a highly practical REM resin. Exploiting this concept, the resulting triazolylmethyl acrylate (TMA) resin was used for an efficient parallel synthesis of tertiary amines by Michael addition, subsequent quarternization and cleavage by means of beta-elimination. (C) 2004 Elsevier Ltd. All rights reserved.