2-(3-(4-trifluoromethylbenzyloxy)phenyl)acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-(4-trifluoromethylbenzyloxy)phenyl)acetic acid
• 英文别名: 2-(3-(4-(Trifluoromethyl)benzyloxy)phenyl)acetic acid；2-[3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]acetic acid
• 化学式: C₁₆H₁₃F₃O₃
• 分子量: 310.273
• InChiKey: AIGJLICYGOIEDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-羟基苯乙酸 在 水 、 potassium carbonate 、 对甲苯磺酸 、 sodium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 2-(3-(4-trifluoromethylbenzyloxy)phenyl)acetic acid
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHOD FOR REDUCING URIC ACID
  [FR] COMPOSÉS ET PROCÉDÉ DE RÉDUCTION DE L'ACIDE URIQUE

  摘要：

  公开号：

  WO2009151695A4

文献信息

• Synthesis and Aldose Reductase Inhibitory Activities of NovelO-Substituted Hydroxyphenylacetic Acid Derivatives
  作者：Dietmar Rakowitz、Helga Angerer、Barbara Matuszczak

  DOI：10.1002/ardp.200600024

  日期：2006.10

  novel aldose reductase inhibitors, several O‐substituted hydroxyphenylacetic acid derivatives were investigated. The highest inhibitory activity was found for compounds 7b and 7c bearing a cyclohexylmethyl substituent. This result demonstrates that within these series, this moiety is a useful surrogate for the 4‐bromo‐2‐fluorobenzyl residue which can be often found in potent aldose reductase inhibitors

  为了继续我们旨在制备新型醛糖还原酶抑制剂的工作，研究了几种 O 取代的羟基苯乙酸衍生物。发现带有环己基甲基取代基的化合物 7b 和 7c 的抑制活性最高。该结果表明，在这些系列中，该部分是 4-溴-2-氟苄基残基的有用替代物，该残基通常可在有效的醛糖还原酶抑制剂中找到。
• COMPOUNDS AND METHOD FOR REDUCING URIC ACID
  申请人：O'NEIL Rita M.

  公开号：US20130259850A1

  公开（公告）日：2013-10-03

  Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; m+n is not more than 4; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R 6 is hydrogen, methyl or ethyl and R 12 is hydrogen or methyl, or R 6 is hydroxy and R 12 is hydrogen, or R 6 is O and R 12 is absent, or R 6 and R 12 together are —CH 2 CH 2 —. R 7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R 8 and R 9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R 10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R 11 ) wherein R 11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula I by a ring carbon; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula I are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, and cognitive impairment.

  在哺乳动物主体中，通过给予化合物I的一个衍生物或其药学上可接受的盐，可以降低尿酸并增加尿酸的排泄。在公式I中，m为0、1、2、3或4；n为0或1；m+n不超过4；t为0或1；q为0或1；r为0、1或2。R6为氢、甲基或乙基，R12为氢或甲基，或者R6为羟基且R12为氢，或者R6为O且R12不存在，或者R6和R12共同为—CH2CH2—。R7为氢或有1至3个碳原子的烷基。R8和R9中的一个为有1至3个碳原子的烷基，另一个为氢或有1至3个碳原子的烷基。R10为氢、卤素、有1至3个碳原子的烷基或有1至3个碳原子的烷氧基。X为C（O），r为0且t为0；或X为NH（R11），其中R11为氢或有1至3个碳原子的烷基。A为苯基，未取代或取代为1或2个从卤素、羟基、甲基、乙基、全氟甲基、甲氧基、乙氧基和全氟甲氧基中选择的基团；或为有1或2个从N、S和O中选择的环杂原子的5或6成员杂环芳基环，且该杂环芳基环通过一个环碳原子与公式I的其余部分共价结合；或为有3至6个环碳原子的环烷基，其中环烷基未取代或其中一或两个环碳原子独立地被甲基或乙基单取代。公式I的降低尿酸作用可用于治疗或预防多种疾病，包括痛风、高尿酸血症、尿酸水平升高但不符合惯常诊断高尿酸血症的水平、肾功能障碍、肾结石、心血管疾病、发生心血管疾病的风险、肿瘤溶解综合征和认知障碍。
• Compounds and method for reducing uric acid
  申请人：O'Neil James Dennen

  公开号：US08829058B2

  公开（公告）日：2014-09-09

  Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula I by a ring carbon; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula I are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, and cognitive impairment.

  通过给予公式I或其药学上可接受的盐，可以降低哺乳动物主体中的尿酸，并增加尿酸的排泄。在公式I中，m为0、1、2、3或4；n为0或1；t为0或1；q为0或1；r为0、1或2。R6为氢、O或羟基。R7为氢或具有1至3个碳原子的烷基。R8和R9中的一个为具有1至3个碳原子的烷基，另一个为氢或具有1至3个碳原子的烷基。R10为氢、卤素、具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基。X为C（O），r为0且t为0；或X为NH（R11），其中R11为氢或具有1至3个碳原子的烷基。A为苯基，未取代或取代为1或2个选自卤素、羟基、甲基、乙基、全氟甲基、甲氧基、乙氧基和全氟甲氧基的基团；或具有1或2个选自N、S和O的环异芳基环，该杂环由环碳原子与公式I的余部共价结合；或具有3至6个环碳原子的环烷基，其中环烷基未取代或一个或两个环碳原子独立地被甲基或乙基单取代。公式I化合物的降尿酸作用可用于治疗或预防各种疾病，包括痛风、高尿酸血症、尿酸水平升高但不符合通常诊断高尿酸血症的水平、肾功能障碍、肾结石、心血管疾病、患心血管疾病的风险、肿瘤溶解综合征和认知障碍。
• EP2268141A1
  申请人：——

  公开号：EP2268141A1

  公开（公告）日：2011-01-05
• COMPOUND AND METHOD FOR REDUCING URIC ACID
  申请人：Wellstat Therapeutics Corporation

  公开号：EP2268141B1

  公开（公告）日：2019-05-08