[N,N-di-(4,4-di-p-methoxyphenylbut-3-enyl)-3-(trifluoromethyl)]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [N,N-di-(4,4-di-p-methoxyphenylbut-3-enyl)-3-(trifluoromethyl)]aniline
• 英文别名: N,N-bis[4,4-bis(4-methoxyphenyl)but-3-enyl]-3-(trifluoromethyl)aniline
• 化学式: C₄₃H₄₂F₃NO₄
• 分子量: 693.806
• InChiKey: AIOPFIQOAMPWLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.8
• 重原子数：
  51
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  40.2
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  [1-(4-甲氧基苯基)-4-甲氧基亚苄基]环丙烷 、 间氨基三氟甲苯 在 tin(II) trifluoromethanesulfonate 、 二氧化碳 、 八氟甲苯 作用下， 40.0 ℃ 、10.0 MPa 条件下， 反应 24.0h， 以74%的产率得到[N,N-di-(4,4-di-p-methoxyphenylbut-3-enyl)-3-(trifluoromethyl)]aniline
  参考文献：
  名称：

  Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon

  摘要：

  The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO(2)) or modified scCO(2) with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(03)00083-6

文献信息

• A novel ring-opening reaction of methylenecyclopropanes with aromatic amines catalyzed by Lewis acids
  作者：Min Shi、Yu Chen、Bo Xu、Jie Tang

  DOI：10.1016/s0040-4039(02)01984-6

  日期：2002.11

  Methylenecyclopropanes (MCPs) can react with aromatic amines to give the corresponding homoallylic amines in good to high yields in the presence of Lewis acids. The substituents on the benzene ring of the MCPs or the aromatic amines can affect significantly the reaction rate.

  亚甲基环丙烷（MCP）可在路易斯酸存在下与芳族胺反应，以高至高收率得到相应的均烯丙基胺。MCP的苯环或芳族胺上的取代基会显着影响反应速率。
• Lewis acids catalyzed ring-opening reactions of methylenecyclopropanes and epoxides in supercritical carbon dioxide or modified supercritical carbon dioxide with perfluorocarbon
  作者：Min Shi、Yu Chen

  DOI：10.1016/s0022-1139(03)00083-6

  日期：2003.8

  The reactions of methylenecyclopropanes (MCPs) and epoxides with alcohols and aromatic amines can be carried out in supercritical carbon dioxide (scCO(2)) or modified scCO(2) with perfluorocarbon which offer a way to synthesize various alcohols, amino-alcohols, homoallylic ethers, and amines under an environmentally benign condition. (C) 2003 Elsevier Science B.V. All rights reserved.