N,N'-(phenylmethylene)bis(trifluoroacetamide)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(phenylmethylene)bis(trifluoroacetamide)
• 英文别名: N,N-Phenylidene bis(trifluoroacetyl)amide；2,2,2-trifluoro-N-[phenyl-[(2,2,2-trifluoroacetyl)amino]methyl]acetamide
• 化学式: C₁₁H₈F₆N₂O₂
• 分子量: 314.187
• InChiKey: AOBFDTMDSJJSQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2,2-三氟乙酰胺 、 苯甲醛 在 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以87%的产率得到N,N'-(phenylmethylene)bis(trifluoroacetamide)
  参考文献：
  名称：

  Synthesis of fluorine-containing symmetrical N,N-alkylidene bisamides

  摘要：

  Fluorine-containing N,N-alkylidene bisamides RCH(NHCORf)(2) (R: H, Aryl; R-f: CF3, CF2Cl, 2,6-C6H3F2) are conveniently prepared in good yields by the reaction of corresponding aldehydes with fluorine-containing amides (RtCONH(2)) in the presence of fluoroalkanesulfonic acids R-f'SO3H(R-f': CF3, HCF2CF2, ICF2CF2OCF2CF2). (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(98)00286-3

文献信息

• Oxidative trifluoroacetamidation of (1E,3E)-1,4-diphenylbuta-1,3-diene and 1,1,4,4-tetraphenylbuta-1,3-diene
  作者：V. V. Astakhova、M. Yu. Moskalik、B. A. Shainyan

  DOI：10.1134/s1070428017070041

  日期：2017.7

  Reactions of trifluoroacetamide with (1E,3E)-1,4-diphenylbuta-1,3-diene and 1,1,4,4-tetraphenylbuta-1,3-diene in the oxidative system t-BuOCl-NaI have been studied. The reaction with (1E,3E)-1,4-diphenylbuta-1,3-diene afforded three products, N,N'-(phenylmethylene)bis(trifluoroacetamide), 3-chloro-4-iodo- 2,5-diphenyl-1-(trifluoroacetyl)pyrrolidine, and trifluoro-N-[(3E)-2-hydroxy-1,4-diphenylbut-3-en-1-yl]acetamide, with a high overall yield. 1,1,4,4-Tetraphenylbuta-1,3-diene failed to react with trifluoroacetamide.
• Synthesis of fluorine-containing symmetrical N,N-alkylidene bisamides
  作者：Shizheng Zhu、Guolin Xu、Qianli Chu、Yong Xu、Chaoyue Qui

  DOI：10.1016/s0022-1139(98)00286-3

  日期：1999.1

  Fluorine-containing N,N-alkylidene bisamides RCH(NHCORf)(2) (R: H, Aryl; R-f: CF3, CF2Cl, 2,6-C6H3F2) are conveniently prepared in good yields by the reaction of corresponding aldehydes with fluorine-containing amides (RtCONH(2)) in the presence of fluoroalkanesulfonic acids R-f'SO3H(R-f': CF3, HCF2CF2, ICF2CF2OCF2CF2). (C) 1999 Elsevier Science S.A. All rights reserved.