三氟甲磺酸环戊酯 | 131929-89-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 三氟甲磺酸环戊酯
• 英文名称: Cyclopentyl trifluoromethanesulfonate
• CAS: 131929-89-0
• 化学式: C₆H₉F₃O₃S
• 分子量: 218.197
• InChiKey: PZSMRYIWZCBSRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(2,4-二氯l苯基)-2-(1H-1,2,4-噻唑-1-基)-乙酮 、 三氟甲磺酸环戊酯 在 N,N-二甲基丙烯基脲 、 sodium hydride 作用下， 生成 1-[(Z)-2-Cyclopentyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
  参考文献：
  名称：

  Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

  摘要：

  Heterocyclic enol ethers of type 1 were studied with respect to the inhibition of 1S,3R-ACPD (10 mu M)stimulated GTP gamma(35)S binding on rat mGluR2 transfected cell membranes. The structure activity relationship with regard to the substitution pattern of the phenyl ring, the oxygen substituent and the nature of the heterocycle is discussed, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00346-7

文献信息

• Organic Compounds
  申请人：Bebernitz Gregory Raymond

  公开号：US20080312256A1

  公开（公告）日：2008-12-18

  The present invention provides compounds of the formula which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, type 2 diabetes and obesity.

  本发明提供了以下式子的化合物，它们是葡萄糖激酶活性的激活剂，因此可以作为治疗葡萄糖激酶介导疾病的治疗剂。因此，式（I）的化合物可用于预防和治疗糖耐量受损、2型糖尿病和肥胖症。
• Thiazolo[5,4-B]pyridine glucokinase activators
  申请人：Novartis AG

  公开号：US08252931B2

  公开（公告）日：2012-08-28

  The present invention provides compounds of the formula which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, type 2 diabetes and obesity.

  本发明提供了式子（I）的化合物，它们是葡萄糖激酶活性的激活剂，因此可以作为治疗葡萄糖激酶介导疾病的治疗剂。因此，式（I）的化合物可用于预防和治疗糖耐量受损、2型糖尿病和肥胖症。
• Tricyclic compounds having fungicidal activity, their preparation and their use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0807631A1

  公开（公告）日：1997-11-19

  Compounds of formula (I): [in which: R1 represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, or cycloalkyloxy; R2 represents hydrogen or halogen; R3 represents hydrogen, alkyl, or cycloalkyl; and the dotted line represents a single or double carbon-carbon bond]; and salts thereof have valuable fungicidal activities which make them of considerable value in agriculture and horticulture.

  式(I)化合物： 其中R1 代表卤素、烷基、卤代烷基、烷氧基、卤代烷氧基、环烷基或环烷氧基；R2 代表氢或卤素；R3 代表氢、烷基或环烷基；虚线代表单碳碳键或双碳碳键]；及其盐类具有重要的杀菌活性，使其在农业和园艺领域具有相当大的价值。
• Sulfonamide derivatives as glycokinase activators useful in the treatment of type 2 diabetes
  申请人：Novartis AG

  公开号：EP2298779A1

  公开（公告）日：2011-03-23

  The present invention provides compounds of the formula which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (1) may be employed for the prevention and the-treatment of impaired glucose tolerance, type 2 diabetes and obesity,

  本发明提供了如下式子的化合物 是葡萄糖激酶活性的激活剂，因此可用作治疗葡萄糖激酶介导的疾病的治疗剂。因此，式（1）化合物可用于预防和治疗糖耐量受损、2 型糖尿病和肥胖症、
• PROCESS FOR PRODUCING ANILINE DERIVATIVE
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0659735B1

  公开（公告）日：1999-01-13