2-(2-hydroxyethoxy)isonicotic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-hydroxyethoxy)isonicotic acid
• 英文别名: 2-(2-Hydroxyethoxy)isonicotinic acid；2-(2-hydroxyethoxy)pyridine-4-carboxylic acid
• 化学式: C₈H₉NO₄
• 分子量: 183.164
• InChiKey: ARKXQTFCUAPJQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯异烟酸 、 乙二醇 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 16.0h， 以34%的产率得到2-(2-hydroxyethoxy)isonicotic acid
  参考文献：
  名称：

  一种螺环衍生物、其制备方法及其在医药上的应用

  摘要：

  本发明涉及一种螺环衍生物、其制备方法及其在医药上的应用。具体而言，本公开涉及一种通式(I)所示的螺环衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂的用途，特别是作为RAF抑制剂的用途和用于制备治疗或预防过渡表达RAF活性相关的各种疾病(包括癌症)药物中的用途。

  公开号：

  CN113264945B

文献信息

• Organic compounds
  申请人：Novartis AG

  公开号：EP2177518A1

  公开（公告）日：2010-04-21

  3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4-substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula I, wherein the symbols have the meanings defined in the specification.

  3,4-取代的哌啶化合物，这些化合物用于温血动物的诊断和治疗，特别是用于治疗依赖于肾素活性的疾病（=失调）；该类化合物用于制备治疗依赖于肾素活性的疾病的药物制剂；公开了该类化合物在治疗依赖肾素活性的疾病中的用途；包含3,4-取代的哌啶化合物的药物制剂，和/或包括施用3,4-取代的哌啶化合物的治疗方法，3,4-取代的哌啶化合物的制造方法，以及新型中间体及其合成的部分步骤。3,4-二取代哌啶化合物具有式 I、 其中符号具有本说明书中定义的含义。
• 2-Acylaminothiazole derivative or salt thereof
  申请人：Astellas Pharma Inc.

  公开号：EP2314586A1

  公开（公告）日：2011-04-27

  A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl- Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.

  一种 2-酰氨基噻唑衍生物或其药学上可接受的盐，具有使人类 c-mpl- Ba/F3 细胞增殖的良好效果，以及基于促进巨核细胞集落形成的效果而增加血小板的活性。一种用于治疗血小板减少症的化合物或其药学上可接受的盐。
• 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
  申请人：Astellas Pharma Inc.

  公开号：EP1466912B1

  公开（公告）日：2013-04-24
• SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS
  申请人：Novartis AG

  公开号：EP1833816A1

  公开（公告）日：2007-09-19
• ORGANIC COMPOUNDS
  申请人：Breitenstein Werner

  公开号：US20090312304A1

  公开（公告）日：2009-12-17

  3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4-substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula I,