9-(3-oxo-2-triphenylphosphoranyliden-5-trimethylsilyl-4-pentynyliden)fluorene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-(3-oxo-2-triphenylphosphoranyliden-5-trimethylsilyl-4-pentynyliden)fluorene
• 英文别名: 5-Fluoren-9-ylidene-1-trimethylsilyl-4-(triphenyl-lambda5-phosphanylidene)pent-1-yn-3-one；5-fluoren-9-ylidene-1-trimethylsilyl-4-(triphenyl-λ5-phosphanylidene)pent-1-yn-3-one
• 化学式: C₃₉H₃₃OPSi
• 分子量: 576.75
• InChiKey: ASNMDBZWGHBGRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.72
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,5-双(三甲硅烷基)五-1,4-二炔-3-酮 、 9-亚芴基三苯基膦烷 以 四氢呋喃 、 乙醚 、 甲苯 为溶剂， 反应 8.0h， 以35%的产率得到9-(3-oxo-2-triphenylphosphoranyliden-5-trimethylsilyl-4-pentynyliden)fluorene
  参考文献：
  名称：

  Synthesis and cytostatic activity of enynes, enediynes and dienediynes linked to intercalators

  摘要：

  We describe here the synthesis of several compounds that include intercalators such as naphthalimide or fluorene, linked to different systems of double and triple bonds. An unusual behaviour of the 9-fluorenylidenetriphenylphosphorane 9 with acetylenic carbonyl compounds, bath aldehyde or ketone, is also reported. The isolated products are the result of a [2+2] cycloaddition between the triple bond and the C=P double bond, unreported for acetylenic aldehydes or ketones. None or the compounds described have shown any interesting cytotoxic activity.

  DOI：

  10.1016/0040-4020(95)00510-f

文献信息

• Synthesis and cytostatic activity of enynes, enediynes and dienediynes linked to intercalators
  作者：Miguel F. Braña、Marina Morán、María Jesús Pérez de Vega、Isabel Pita-Romero、Nigel Walker

  DOI：10.1016/0040-4020(95)00510-f

  日期：1995.8

  We describe here the synthesis of several compounds that include intercalators such as naphthalimide or fluorene, linked to different systems of double and triple bonds. An unusual behaviour of the 9-fluorenylidenetriphenylphosphorane 9 with acetylenic carbonyl compounds, bath aldehyde or ketone, is also reported. The isolated products are the result of a [2+2] cycloaddition between the triple bond and the C=P double bond, unreported for acetylenic aldehydes or ketones. None or the compounds described have shown any interesting cytotoxic activity.