(2E,5Z)-2-[(5-chloro-2-methylphenyl)imino]-5-{[1-(4-hydroxyphenyl)-1H-pyrrol-2-yl]methylidene}-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (2E,5Z)-2-[(5-chloro-2-methylphenyl)imino]-5-{[1-(4-hydroxyphenyl)-1H-pyrrol-2-yl]methylidene}-1,3-thiazolidin-4-one
• 英文别名: (5Z)-2-(5-chloro-2-methylphenyl)imino-5-[[1-(4-hydroxyphenyl)pyrrol-2-yl]methylidene]-1,3-thiazolidin-4-one
• 化学式: C₂₁H₁₆ClN₃O₂S
• 分子量: 409.9
• InChiKey: ANALGJDPODAEQV-UNOMPAQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation
  申请人：Universität Bern

  公开号：EP2952188A1

  公开（公告）日：2015-12-09

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

  本发明涉及一种由以下通式（1）组成的化合物，用于治疗精神或神经疾病和炎症，尤其是神经炎症： 其中 R1、R2 和 R3 各自独立地选自烷基、烷氧基、烯基、炔基、环烷基、芳基、杂环或杂芳基。
• THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION
  申请人：UNIVERSITÄT BERN

  公开号：US20170296515A1

  公开（公告）日：2017-10-19

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.
• [EN] THIAZOLIDINONES AS CELLULAR ANANDAMIDE UPTAKE INHIBITORS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION<br/>[FR] THIAZOLIDINONES EN TANT QU'INHIBITEURS D'ABSORPTION D'ANANDAMIDE CELLULAIRE ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES PSYCHIATRIQUES OU NEUROLOGIQUES ET DE L'INFLAMMATION, EN PARTICULIER LA NEURO-INFLAMMATION
  申请人：UNIVERSITÄT BERN

  公开号：WO2015181336A1

  公开（公告）日：2015-12-03

  The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R 2 and R 3 are selected independently from each other from alkyl, alkoxy, alkenyl,alkynyl,cycloalkyl, aryl,heterocycle or heteroaryl.