5-cyclohexyloxymethyl-benzo[1,3]dioxole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-cyclohexyloxymethyl-benzo[1,3]dioxole
• 英文别名: 5-(Cyclohexyloxymethyl)-1,3-benzodioxole
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: ATGNXIPOCIWOJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苯基-1-三甲基硅氧乙烯 、 5-cyclohexyloxymethyl-benzo[1,3]dioxole 在 4 A molecular sieve 、 lithium perchlorate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到3-(1,3-Benzodioxol-5-yl)-3-cyclohexyloxy-1-phenylpropan-1-one
  参考文献：
  名称：

  富电子的烷基苄基醚与三甲基乙烯基氧基硅烷的氧化CC键形成反应。

  摘要：

  在室温下用DDQ处理富电子苄基醚，然后加入甲硅烷基烯醇醚进行CC键形成反应，得到3-烷氧基-3-苯基-丙酰基化合物。这是一般反应，可与多种甲硅烷基烯醇醚很好地反应，以10至85％的收率得到羰基产物。

  DOI：

  10.1021/ol036314j

文献信息

• Melanogenesis inhibitor and skin preparation containing the same
  申请人：Ishida Kenya

  公开号：US20060088485A1

  公开（公告）日：2006-04-27

  A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.

  一种黑色素生成抑制剂，其特征在于包含至少一种由下述通式（1）表示的香豆素醇，其中R为直链或支链烷基，具有3至18个碳原子，直链或支链烯基，具有3至18个碳原子，或是可选择性取代的脂环烷基。该黑色素生成抑制剂具有较高的稳定性和安全性，并具有较强的黑色素生成抑制效果；含有该黑色素生成抑制剂的皮肤制剂非常稳定、安全，具有足够的美白效果和治疗皮肤色素沉着的效果。
• COMPOSITION FOR DYEING KERATIN FIBERS
  申请人：L'OREAL

  公开号：EP3386470A1

  公开（公告）日：2018-10-17
• US7576125B2
  申请人：——

  公开号：US7576125B2

  公开（公告）日：2009-08-18
• [EN] MELANOGENESIS INHIBITOR AND SKIN PREPARATION CONTAINING THE SAME<br/>[FR] INHIBITEUR DE MELANOGENESE ET PREPARATION DERMATOLOGIQUE CONTENANT CELUI-CI
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2004071481A1

  公开（公告）日：2004-08-26

  A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 13 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 13 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.
• [EN] COMPOSITION FOR DYEING KERATIN FIBERS<br/>[FR] COMPOSITION DE COLORATION DES FIBRES DE KÉRATINE
  申请人：OREAL

  公开号：WO2017094866A1

  公开（公告）日：2017-06-08

  The present invention relates to a composition for dyeing keratin fibers, comprising (a) at least one direct dye; and (b) at least one oxygen-containing polycyclic compound which has at least one oxygen-containing polycyclic ring. The composition according to the present invention may further include (c) at least one specific sulfone compound. The composition according to the present invention is a one-part composition and can prevent or reduce skin staining by the direct dye on the skin such as the scalp, while providing the keratin fibers with good cosmetic effects such as good coloring properties.