4,5-dimethyl-[1,1′-biphenyl]-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-dimethyl-[1,1′-biphenyl]-2-carboxylic acid
• 英文别名: 4,5-dimethyl-biphenyl-2-carboxylic acid；4,5-Dimethyl-biphenyl-2-carbonsaeure；4,5-Dimethyl-2-phenylbenzoic acid
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: AUJPHGZVBPNUHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5-dimethyl-[1,1′-biphenyl]-2-carboxylic acid 在 Pd(OTf)₂ 、 异氰酸叔丁酯 、 水 、 silver carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以78%的产率得到2,3-dimethyl-9H-fluoren-9-one
  参考文献：
  名称：

  One-Pot Palladium(II)-Catalyzed Synthesis of Fluorenones via Decarboxylative Cyclization

  摘要：

  A one-pot palladium-catalyzed synthesis of fluoronones via decarboxylative cyclization is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive experimental data, we propose a plausible decarboxylative insertion mechanism.

  DOI：

  10.1055/s-0035-1560527
• 作为产物：
  描述：

  3,4-二甲基-6-苯基环己-3-烯羧酸 在 sulfur 作用下， 生成 4,5-dimethyl-[1,1′-biphenyl]-2-carboxylic acid
  参考文献：
  名称：

  DE720827

  摘要：

  公开号：

文献信息

• Heterocyclic amide compounds as apolipoprotein b inhibitors
  申请人：Takasugi Hisashi

  公开号：US20050038035A1

  公开（公告）日：2005-02-17

  The present invention relates to a compound of the formula (I) wherein R 1 is optionally substituted aryl; R 2 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted lower cycloalkyl, optionally substituted aryloxy, optionally substituted arylsulfonyl, vinyl, carbamoyl, protected carboxy or protected amino; ring A is bivalent residue derived from optionally substituted aryl or optionally substituted heteroaryl; X is bivalent residue derived from the group consisting of cycloalkene, naphthalene, unsaturated 5 or 6-membered heteromonocyclic group, each of which is optionally substituted, and substituted benzene; Y is -(A 1 ) m1 -(A 2 ) m2 -; and Z is direct bond or piperazine, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

  本发明涉及一种化合物，其分子式为（I），其中R1为可选取代芳基；R2为可选取代芳基、可选取代杂环芳基、可选取代较低环烷基、可选取代芳氧基、可选取代芳基磺酰基、乙烯基、氨基甲酰基、保护羧基或保护氨基；环A为由可选取代芳基或可选取代杂环芳基衍生的二价残基；X为由环烷烯、萘、不饱和的5或6元杂单环基衍生的二价残基，每种残基均可选取代，以及取代苯基；Y为-(A1)m1-(A2)m2-；Z为直接键或哌嗪，或其盐。本发明的化合物及其盐能抑制载脂蛋白B（Apo B）的分泌，并可用作预防和治疗由于高循环Apo B水平引起的疾病或病症的药物。
• DE720827
  申请人：——

  公开号：——

  公开（公告）日：——
• 10.1021/acs.joc.4c00643
  作者：Wang, Jie、Li, Yao-Dong、Ge, Ye、Xu, Hua-Jin、Hu, Yi

  DOI：10.1021/acs.joc.4c00643

  日期：——
• One-Pot Palladium(II)-Catalyzed Synthesis of Fluorenones via Decarboxylative Cyclization
  作者：Zhiqiang Cai、Xu Hou、Ling Hou、Zhiquan Hu、Bo Zhang、Zhengsheng Jin

  DOI：10.1055/s-0035-1560527

  日期：——

  A one-pot palladium-catalyzed synthesis of fluoronones via decarboxylative cyclization is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive experimental data, we propose a plausible decarboxylative insertion mechanism.
• Aromatic polynuclear polycarboxylic acids and a process of making them
  申请人：IG FARBENINDUSTRIE AG

  公开号：US02197880A1

  公开（公告）日：1940-04-23