4-amino-4-[3-(benzyloxy)propyl]-1,7-di(benzyloxy)heptane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-4-[3-(benzyloxy)propyl]-1,7-di(benzyloxy)heptane
• 英文别名: 1,7-Bis(phenylmethoxy)-4-(3-phenylmethoxypropyl)heptan-4-amine
• 化学式: C₃₁H₄₁NO₃
• 分子量: 475.671
• InChiKey: AUQADNDIEPVUTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  硝基甲烷三丙酸 、 4-amino-4-[3-(benzyloxy)propyl]-1,7-di(benzyloxy)heptane 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 4-{2-[4-Benzyloxy-1,1-bis-(3-benzyloxy-propyl)-butylcarbamoyl]-ethyl}-4-nitro-heptanedioic acid bis-{[4-benzyloxy-1,1-bis-(3-benzyloxy-propyl)-butyl]-amide}
  参考文献：
  名称：

  Synthesis of benzyl-terminated dendrons for use in high-resolution capillary gas chromatography

  摘要：

  The synthesis, silane functionalization, and facile silica attachment of dendritic monomers containing terminal benzyl groups are presented. For the first time, a simple one-step procedure is described that leads to the in situ creation of a surface-bonded sol-gel dendritic stationary phase on the inner walls of a fused silica capillary; such phases showed unique selectivities in high-resolution capillary gas chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01642-2

文献信息

• Sol-gel dendron separation and extraction capillary column
  申请人：Malik Abdul

  公开号：US20050106068A1

  公开（公告）日：2005-05-19

  The present invention provides for a capillary column including a tube structure having an inner surface and a sol-gel substrate bonded to a dendrimer substrate to form a sol-gel dendrimer matrix that bonds to a portion of the inner surface of the tube structure to form a surface-bonded stationary phase coating thereon. The present invention additionally provides for a capillary column including a tube structure having an inner surface, a stationary phase coating attached to a portion of the inner surface, and a dendrimer moiety bonded to the stationary phase coating. Further, a sol-gel dendrimer coated apparatus including a structure having a surface and a sol-gel substrate bonded to a dendrimer substrate to form a sol-gel dendrimer matrix coating the surface thereon is provided. The present invention also provides for a one-step method for making and preparing a column and a method of making the sol-gel and dendrimer solution.

  本发明提供了一种毛细管柱，包括具有内表面的管状结构和与树枝状聚合物基底粘合以形成溶胶凝胶树枝状聚合物基质的溶胶凝胶基底，该基质与管状结构的部分内表面粘合以在其上形成表面粘合固定相涂层。本发明还提供了一种毛细管柱，包括具有内表面的管状结构、附着在部分内表面上的固定相涂层以及与固定相涂层结合的树枝状聚合物分子。此外，本发明还提供了一种溶胶-凝胶树枝状聚合物涂层装置，包括具有表面的结构和与树枝状聚合物基底粘合以形成涂覆其表面的溶胶-凝胶树枝状聚合物基质的溶胶-凝胶基底。本发明还提供了一种一步法制作和制备色谱柱的方法，以及一种制作溶胶-凝胶和树枝状聚合物溶液的方法。
• Synthesis of benzyl-terminated dendrons for use in high-resolution capillary gas chromatography
  作者：George R Newkome、Kyung Soo Yoo、Abuzar Kabir、Abdul Malik

  DOI：10.1016/s0040-4039(01)01642-2

  日期：2001.10

  The synthesis, silane functionalization, and facile silica attachment of dendritic monomers containing terminal benzyl groups are presented. For the first time, a simple one-step procedure is described that leads to the in situ creation of a surface-bonded sol-gel dendritic stationary phase on the inner walls of a fused silica capillary; such phases showed unique selectivities in high-resolution capillary gas chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.