1-(2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-(2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one
• 英文别名: 1-(1-indanyl)-2-pyrrolidinone
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: AYRRPBGRVWLOMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-茚酮 、 4-氨基丁酸 在 苯硅烷 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以10%的产率得到1-(2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one
  参考文献：
  名称：

  氢化硅烷化条件下羰基衍生物与 ω-氨基酸的还原胺化合成内酰胺

  摘要：

  开发了一种前所未有的有效方法，用于在氢化硅烷化条件下用ω-氨基脂肪酸还原胺化羰基衍生物，从而产生相应的内酰胺。制备了多种吡咯烷酮、哌啶酮、2-氮杂环庚酮，分离产率高达 95%（29 个实施例）。

  DOI：

  10.1002/ejoc.202100719

文献信息

• Prophylactic/Therapeutic Agent for Diabetes
  申请人：Cho Nobuo

  公开号：US20090264650A1

  公开（公告）日：2009-10-22

  The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.

  本发明涉及一种11β-羟基类固醇脱氢酶1抑制剂，其包括由式（1）表示的化合物，其中每个符号如描述中所定义的，或其盐或前药。本发明的11β-羟基类固醇脱氢酶1抑制剂具有优异的活性，可用作药物剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖症、异常脂质代谢、高血压等的药剂。
• PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1864971A1

  公开（公告）日：2007-12-12

  The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.

  本发明涉及一种 11β-羟基类固醇脱氢酶 1 抑制剂，由式（1）代表的化合物组成： 其中各符号如说明中所定义，或其盐，或其原药。本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性，可作为药物制剂，如用于预防或治疗糖尿病、胰岛素抵抗、肥胖、脂代谢异常、高血压等疾病的药物。
• Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids
  作者：Kristina M. Orrling、Xiongyu Wu、Francesco Russo、Mats Larhed

  DOI：10.1021/jo8015264

  日期：2008.11.7

  A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Bronsted acid. obtained in useful to excellent yields after only 35 min of microwave processing.