4,5-bis(4-bromophenyl)-2-(3-(4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)phenyl)oxazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,5-bis(4-bromophenyl)-2-(3-(4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)phenyl)oxazole
• 英文别名: 4,5-Bis(4-bromophenyl)-2-[3-[4-(6-methoxynaphthalen-2-yl)triazol-1-yl]phenyl]-1,3-oxazole；4,5-bis(4-bromophenyl)-2-[3-[4-(6-methoxynaphthalen-2-yl)triazol-1-yl]phenyl]-1,3-oxazole
• 化学式: C₃₄H₂₂Br₂N₄O₂
• 分子量: 678.382
• InChiKey: AZNFPOHEBZNQPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  66
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-双(4-溴苯基)-2-羟基乙酮 在 4-二甲氨基吡啶 、 copper(ll) sulfate pentahydrate 、 ammonium acetate 、 溶剂黄146 、 sodium ascorbate 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 35.0h， 生成 4,5-bis(4-bromophenyl)-2-(3-(4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)phenyl)oxazole
  参考文献：
  名称：

  1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation

  摘要：

  The development and use of small-molecule inhibitors of the adherence of Porphyromonas gingivalis to oral streptococci represents a potential therapy for the treatment of periodontal disease as these organisms work in tandem to colonize the oral cavity. Earlier work from these laboratories demonstrated that a small synthetic peptide was an effective inhibitor of the interaction between P. gingivalis and Streptococcus gordonii and that a small-molecule peptidomimetic would provide a more stable, less expensive and more effective inhibitor. An array of 2-(azidomethyl)- and 2-(azidophenyl)-4,5-diaryloxazoles having a full range of hydrophobic groups were prepared and reacted with substituted arylacetylenes to afford the corresponding 'click' products. The title compounds were evaluated for their ability to inhibit P. gingivalis' adherence to oral streptococci and several were found to be inhibitory in the range of (IC50) 5.3-67 mu M. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicensesiby-nc-nd/4.0/).

  DOI：

  10.1016/j.bmc.2016.08.059

文献信息

• 1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation
  作者：Pravin C. Patil、Jinlian Tan、Donald R. Demuth、Frederick A. Luzzio

  DOI：10.1016/j.bmc.2016.08.059

  日期：2016.11

  The development and use of small-molecule inhibitors of the adherence of Porphyromonas gingivalis to oral streptococci represents a potential therapy for the treatment of periodontal disease as these organisms work in tandem to colonize the oral cavity. Earlier work from these laboratories demonstrated that a small synthetic peptide was an effective inhibitor of the interaction between P. gingivalis and Streptococcus gordonii and that a small-molecule peptidomimetic would provide a more stable, less expensive and more effective inhibitor. An array of 2-(azidomethyl)- and 2-(azidophenyl)-4,5-diaryloxazoles having a full range of hydrophobic groups were prepared and reacted with substituted arylacetylenes to afford the corresponding 'click' products. The title compounds were evaluated for their ability to inhibit P. gingivalis' adherence to oral streptococci and several were found to be inhibitory in the range of (IC50) 5.3-67 mu M. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicensesiby-nc-nd/4.0/).