三聚(1,3-丙二醇)双丙烯酸酯 | 68901-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 三聚(1,3-丙二醇)双丙烯酸酯
• 英文名称: tripropyleneglycol diacrylate
• 英文别名: Tripropylenglycol-diacrylat；3-[3-(3-prop-2-enoyloxypropoxy)propoxy]propyl prop-2-enoate
• CAS: 68901-05-3
• 化学式: C₁₅H₂₄O₆
• 分子量: 300.352
• InChiKey: FWQJYIDNAYBUMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4,8-二氧杂十一烷-1,11-二醇 、 丙烯酸 生成 三聚(1,3-丙二醇)双丙烯酸酯
  参考文献：
  名称：

  MIYADZAKI, TYUITI;SAJTO, AKIXISA;ANDO, SINYA

  摘要：

  DOI：

文献信息

• Biodegradable poly(beta-amino esters) and uses thereof
  申请人：Massachusetts Institute of Technology (MIT)

  公开号：EP1903068A1

  公开（公告）日：2008-03-26

  Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

  描述了通过双（仲胺）或伯胺与双（丙烯酸酯）共轭加成制备的聚（β-氨基酯）。此外，还提供了用市售起始材料制备这些聚合物的方法。这些含叔胺的聚合物最好具有生物降解性和生物相容性，可用于各种给药系统。鉴于这些聚合物的聚（胺）性质，它们特别适合用于多核苷酸的递送。现已制备出含有聚合物/多核苷酸复合物的纳米颗粒。本发明的聚合物还可用于封装其他需要递送的制剂。由于它们能够缓冲周围环境的 pH 值，因此特别适用于递送易溶制剂。此外，还提供了一种利用半自动机器人流体输送系统平行制备和筛选聚合物的系统。
• CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
  申请人：Anderson Daniel Griffith

  公开号：US20080145338A1

  公开（公告）日：2008-06-19

  Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
• End-Modified Poly(beta-amino esters) and Uses Thereof
  申请人：Zugates Gregory T.

  公开号：US20080242626A1

  公开（公告）日：2008-10-02

  Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110059172A1

  公开（公告）日：2011-03-10

  Therapeutic compositions containing therapeutic agents and poly(beta-amino esters) or polymers thereof are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles and microparticles containing polymer/therapeutic agent complexes are also described.
• END-MODIFIED POLY(BETA-AMINO ESTERS) AND USES THEREOF
  申请人：Zugates Gregory T.

  公开号：US20120149630A1

  公开（公告）日：2012-06-14

  Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.