2,2'-anhydrouridine-5'-triphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 2,2'-anhydrouridine-5'-triphosphate
• 英文别名: [hydroxy-[[(2R,4R,5R,6S)-5-hydroxy-10-oxo-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-4-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• 化学式: C₉H₁₃N₂O₁₄P₃
• 分子量: 466.129
• InChiKey: BCVDHAYEJIHXLG-CCXZUQQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.3
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  231
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  2,2'-脱水尿苷 在 磷酸三甲酯 、 1,8-双二甲氨基萘 、 三氯氧磷 作用下， 反应 2.0h， 生成 2,2'-anhydrouridine-5'-triphosphate
  参考文献：
  名称：

  The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2-Purinergic Receptors

  摘要：

  Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y(2)-purinoceptors were not activated by the ATP analogue, 8,2'-thioanhydroadenosine-5'-triphosphate (4) and only weakly by the UTP analogue, 2,2'-anhydrouridine-5'-triphosphate (6). However, both analogues were agonists for P2X(2)-purinoceptors although the potencies were approximately 30-fold less than that of the parent nucleotides.

  DOI：

  10.1080/15257770008035026

文献信息

• The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2-Purinergic Receptors
  作者：Girolamo Tusa、Juta K. Reed

  DOI：10.1080/15257770008035026

  日期：2000.4

  Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y(2)-purinoceptors were not activated by the ATP analogue, 8,2'-thioanhydroadenosine-5'-triphosphate (4) and only weakly by the UTP analogue, 2,2'-anhydrouridine-5'-triphosphate (6). However, both analogues were agonists for P2X(2)-purinoceptors although the potencies were approximately 30-fold less than that of the parent nucleotides.