4-hydroxy-N-(4-hydroxyphenyl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-N-(4-hydroxyphenyl)benzenesulfonamide
• 化学式: C₁₂H₁₁NO₄S
• 分子量: 265.29
• InChiKey: BCWUBVCTPGTFQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium p-hydroxybenzenesulfonate 在 吡啶 、 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 4-hydroxy-N-(4-hydroxyphenyl)benzenesulfonamide
  参考文献：
  名称：

  WO2006/45010

  摘要：

  公开号：

文献信息

• Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
  申请人：Wong C.W. Norman

  公开号：US20060205792A1

  公开（公告）日：2006-09-14

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供了一些非天然的多酚化合物，这些化合物可以上调载脂蛋白A-I（ApoA-I）的表达。所述的组合物和方法可用于治疗和预防心血管疾病及相关疾病状态，包括胆固醇或脂质相关紊乱，例如动脉粥样硬化。
• Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases
  申请人：Wong Norman C.W.

  公开号：US20110082176A1

  公开（公告）日：2011-04-07

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供非自然产生的多酚化合物，可以上调载脂蛋白A-I（ApoA-I）的表达。所披露的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关的疾病，例如动脉粥样硬化。
• HEAT-SENSITIVE RECORDING MATERIAL
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1466751A1

  公开（公告）日：2004-10-13

  (A) The invention discloses a thermosensitive recording material comprising: a support; and a thermosensitive recording layer formed on the support, the thermosensitive recording layer containing an electron-donating colorless dye and an electron-accepting compound which develops color upon a reaction with the electron-donating colorless dye, wherein the thermosensitive recording material satisfies at least one of the following conditions (1) to (3). (1) an image density when thermal printing is performed from a side, of the support, having the thermosensitive recording layer with printing energy of 15.2 mJ/mm2 is 1.20 or more, and the thermosensitive recording material is used for a recording device having a printing speed of 10 cm/sec or more; (2) the thermosensitive recording material contains a sensitizer comprising at least one compound selected from the group consisting of 2-benzyloxynaphthalene, dimethylbenzyloxalate, m-terphenyl, ethyleneglycol tolyl ether, p-benzyl biphenyl, 1,2-diphenoxymethyl benzene, diphenyl sulfone and 1,2-diphenoxy ethane, and the image density after the thermosensitive recording material is brought into contact with a heat source of 70°C for 5 seconds is 0.15 or less; (3) the electron-accepting compound is a compound represented by the following Formula (1) Formula (1)R1-Ph-SO2R2   wherein R1 represents a hydroxyl group or an alkyl group, R2 represents -Ph, -NH-Ph, -Ph-OR3 or -NH-CO-NH-Ph, R3 represents an alkyl group, Ph represents a phenyl group and may be substituted with a substituent containing -SO2R2, and a volume-averaged grain size of the electron-donating colorless dye and electron-accepting compound is in a range of 0.5 to 1.0 µm. (B) A thermosensitive recording material comprises a thermosensitive recording layer containing an electron-donating colorless dye, an electron-accepting compound which develops color upon a reaction with the electron-donating colorless dye and a sensitizer, wherein the thermosensitive recording material satisfies at least one of the following conditions (1) to (3). (1) An image density when thermal printing is performed with a printing energy is 1.20 or more, and the thermosensitive recording material is used for a recording device having a printing speed of 10 cm/sec or more. (2) An image density after the thermosensitive recording material is brought into contact with a heat source of 70°C for 5 seconds is 0.15 or less, and the sensitizer is 2-benzyloxynaphthalene or the like. (3) the electron-accepting compound is a compound represented by R1-Ph-SO2R2 wherein R1 represents a hydroxyl group or an alkyl group, R2 represents -Ph, -NH-Ph, -Ph-OR3 or -NH-CO-NH-Ph, R3 represents an alkyl group, Ph represents a phenyl group and may be substituted with a substituent containing SO2R2, and a volume-averaged grain size is in a range of 0.5 to 1.0 µm.

  (A) 本发明公开了一种热敏记录材料，包括：支撑物；和形成在支撑物上的热敏记录层，该热敏记录层含有电子捐赠无色染料和电子接受化合物，该电子接受化合物与电子捐赠无色染料反应后显色，其中热敏记录材料至少满足以下条件（1）至（3）中的一个。 (1) 当从具有热敏记录层的支撑物的一侧进行热打印时，打印能量为 15.2 mJ/mm2 的图像密度为 1.20 或以上，且热敏记录材料用于打印速度为 10 厘米/秒或以上的记录设备； (2) 热敏记录材料含有敏化剂，该敏化剂包含至少一种选自以下组别的化合物：2-苄氧基萘、二甲基苄氧基萘、间三联苯、乙二醇对二甲苯醚、对苄基联苯、1,2-二苯氧基甲基苯、二苯砜和 1,2-二苯氧基乙烷，且热敏记录材料与 70°C 的热源接触 5 秒钟后的图像密度为 0.15 或更低； (3) 电子接受化合物是由下式表示的化合物 式(1) 式(1)R1-Ph-SO2R2 其中 R1 代表羟基或烷基，R2 代表-Ph、-NH-Ph、-Ph-OR3 或-NH-CO-NH-Ph，R3 代表烷基，Ph 代表苯基并可被含有-SO2R2 的取代基取代，且电子氖型无色染料和电子接受化合物的体积平均粒度在 0.5至1.0微米。 (B) 一种热敏记录材料，它包括一个热敏记录层，该层含有一种电子致性无色染料、一种电子受体化合物，该化合物在与电子致性无色染料和敏化剂反应后显色，其中热敏记录材料至少满足下列条件(1)至(3)之一。 (1) 当使用打印能量进行热打印时，图像密度为 1.20 或以上，且热敏记录材料用于打印速度为 10 厘米/秒或以上的记录设备。 (2) 热敏记录材料与 70°C 的热源接触 5 秒后的图像密度为 0.15 或更低，且敏化剂为 2-苄氧基萘或类似物。 (3) 电子接受化合物是由 R1-Ph-SO2R2 所代表的化合物，其中 R1 代表羟基或烷基，R2 代表-Ph、-NH-Ph、-Ph-OR3 或-NH-CO-NH-Ph，R3 代表烷基，Ph 代表苯基并可被含有 SO2R2 的取代基取代，且体积平均粒度在 0.5 至 1.0 微米范围内。
• PROCESS FOR PRODUCING GLYCOSIDE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1544207A1

  公开（公告）日：2005-06-22

  A glycoside in which at least two phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule are glycosidically linked to anomeric carbon atoms of at least two sugar molecules can be prepared with high yield by a method including the step of allowing phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule to react with sugar molecules each having an acetylated hydroxyl group attached to an anomeric carbon atom in the presence of an organic solvent and an acid catalyst while removing acetic acid formed during the reaction from the reaction system.

  一种苷，其分子中含有至少两个酚羟基的化合物的至少两个酚羟基与至少两个糖分子的同分异构碳原子糖苷键合，该苷的制备方法收率高，该方法包括以下步骤在有机溶剂和酸催化剂存在下，使分子中含有至少两个酚羟基的化合物的酚羟基与每个具有乙酰化羟基的糖分子发生反应，同时从反应体系中除去反应过程中形成的乙酸。
• Heat-sensitive recording material
  申请人：Iwasaki Masayuki

  公开号：US20050088508A1

  公开（公告）日：2005-04-28

  (A) The invention discloses a thermosensitive recording material comprising: a support; and a thermosensitive recording layer formed on the support, the thermosensitive recording layer containing an electron-donating colorless dye and an electron-accepting compound which develops color upon a reaction with the electron-donating colorless dye, wherein the thermosensitive recording material satisfies at least one of the following conditions (1) to (3). (1) an image density when thermal printing is performed from a side, of the support, having the thermosensitive recording layer with printing energy of 15.2 mJ/mm 2 is 1.20 or more, and the thermosensitive recording material is used for a recording device having a printing speed of 10 cm/sec or more; (2) the thermosensitive recording material contains a sensitizer comprising at least one compound selected from the group consisting of 2-benzyloxynaphthalene, dimethylbenzyloxalate, m-terphenyl, ethyleneglycol tolyl ether, p-benzyl biphenyl, 1,2-diphenoxymethyl benzene, diphenyl sulfone and 1,2-diphenoxy ethane, and the image density after the thermosensitive recording material is brought into contact with a heat source of 70° C. for 5 seconds is 0.15 or less; (3) the electron-accepting compound is a compound represented by the following Formula (1) R 1 -Ph-SO 2 R 2 Formula (1) wherein R 1 represents a hydroxyl group or an alkyl group, R 2 represents -Ph, —NH-Ph, -Ph-OR 3 or —NH—CO—NH-Ph, R 3 represents an alkyl group, Ph represents a phenyl group and may be substituted with a substituent containing —SO 2 R 2 , and a volume-averaged grain size of the electron-donating colorless dye and electron-accepting compound is in a range of 0.5 to 1.0 μm.

  (A) 本发明公开了一种热敏记录材料，包括：支撑物；和在支撑物上形成的热敏记录层，热敏记录层含有电子致色的无色染料和与电子致色的无色染料反应后显色的电子接受化合物，其中热敏记录材料至少满足以下条件(1)至(3)中的一个。 (1) 当从具有热敏记录层的支撑物的一侧进行热打印时，打印能量为 15.2 mJ/mm 的图像密度； (2) 当从具有热敏记录层的支撑物的一侧进行热打印时，打印能量为 15.2 mJ/mm 的图像密度。 2 为 1.20 或更高，且热敏记录材料用于打印速度为 10 厘米/秒或更高的记录设备；(2) 热敏记录材料含有感光剂，该感光剂包含至少一种选自以下组别的化合物：2-苄氧基萘、二甲基苄氧基萘、间三联苯、乙二醇对二甲苯醚、对苄基联苯、1,2-二苯氧基甲基苯、二苯砜和 1,2-二苯氧基乙烷。(3) 电子接收化合物是由下式（1）表示的化合物 R 1 -Ph-SO 2 R 2 式 (1) 其中 R 1 代表羟基或烷基，R 2 代表-Ph、-NH-Ph、-Ph-OR 3 或-NH-CO-NH-Ph，R 3 代表烷基，Ph 代表苯基，可被含有-SO 2 R 2 的体积平均粒径范围为 0.5 至 1.0 μm。