3-(phenyl(p-tolyl)methyl)pentane-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(phenyl(p-tolyl)methyl)pentane-2,4-dione
• 英文别名: 3-(4-methyl-benzhydryl)-pentane-2,4-dione；β.δ-Dioxo-γ-(4-methyl-benzhydryl)-pentan；3-(4-Methyl-benzhydryl)-pentan-2,4-dion；α-(4-Methyl-benzhydryl)-α-acetyl-aceton；3-[(4-Methylphenyl)(phenyl)methyl]-2,4-pentanedione；3-[(4-methylphenyl)-phenylmethyl]pentane-2,4-dione
• 化学式: C₁₉H₂₀O₂
• 分子量: 280.367
• InChiKey: BDMRIQIABQKTQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  34.14
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4-甲基二苯甲醇 、 乙酰丙酮 在 tin ion-exchanged montmorillonite 作用下， 以 1,2-二氯乙烷 为溶剂， 以86%的产率得到3-(phenyl(p-tolyl)methyl)pentane-2,4-dione
  参考文献：
  名称：

  Efficient Nucleophilic Substitution of α-Aryl Alcohols with 1,3-Dicarbonyl Compounds Catalyzed by Tin Ion-Exchanged Montmorillonite

  摘要：

  锡离子交换蒙脱石表现出对α-芳基醇中的羟基与各种1,3-双羰基化合物（包括酸性较弱的1,3-双酯）在粗溶剂中进行直接亲核取代反应的高催化活性，生成伴有水的苄基化产物。

  DOI：

  10.1055/s-0030-1258567

文献信息

• Microwave-Irradiated Transition-Metal Catalysis: Rapid and Efficient Dehydrative Carbon-Carbon Coupling of Alcohols with Active Methylenes
  作者：Akio Baba、Srinivasarao Babu、Makoto Yasuda、Yasunori Tsukahara、Tomohisa Yamauchi、Yuji Wada

  DOI：10.1055/s-2008-1067020

  日期：2008.6

  transition-metal-catalyzed carbon-carbon coupling of a wide range of benzylic/allylic alcohols with β-diones, β-keto esters, and dialkyl malonates is reported. In a representative screening of transition-metal catalysts, salts of Zn, Cu, Fe, Sc, Ru, Pt, Ta, and Mo were found to furnish the coupling products. In light of the results obtained, among all of these catalysts copper(II) triflate was found to be relatively

  报道了一种快速且高效的合成微波辐照方案，用于过渡金属催化的各种苄醇/烯丙醇与 β-二酮、β-酮酯和丙二酸二烷基酯的碳-碳偶联。在对过渡金属催化剂的代表性筛选中，发现 Zn、Cu、Fe、Sc、Ru、Pt、Ta 和 Mo 的盐可以提供偶联产物。鉴于所获得的结果，在所有这些催化剂中，发现与其他催化剂相比，三氟甲磺酸铜 (II) 相对更有效，即使在反应性较低的苯甲醇或二酯的情况下也是如此。有趣的是，这些 MW 辐照反应是在或多或少 MW 透明的介质中进行的，例如甲苯，具有非常低的 tanδ，或在纯净条件下进行。
• Phosphotungstic Acid Catalyzed Direct Benzylation of β-Dicarbonyl Compounds
  作者：Guan-Wu Wang、Ye-Bing Shen、Xue-Liang Wu

  DOI：10.1002/ejoc.200800624

  日期：2008.10

  12-Phosphotungstic acid was used as an efficient, ecofriendly, and air- and moisture-stable catalyst to promote the direct substitution of the hydroxy group of benzylic and allylic alcohols with various β-dicarbonyl compounds. This powerful protocol for carbon–carbon bond-forming reactions provides monoalkylated dicarbonyl compounds in high yields with great efficiency.(© Wiley-VCH Verlag GmbH & Co

  12-磷钨酸被用作一种高效、环保、空气和湿气稳定的催化剂，以促进苯甲醇和烯丙醇的羟基被各种β-二羰基化合物直接取代。这种强大的碳-碳键形成反应方案提供了高产率和高效率的单烷基化二羰基化合物。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008）
• Yb(OTf)3-promoted effective benzylation and allylation with N-tosyl amino group as a stable leaving group
  作者：Jinqian Liu、Limin Wang、Xingzhou Zheng、Aili Wang、Mengyun Zhu、Jianjun Yu、Qiang Shen

  DOI：10.1016/j.tetlet.2012.01.141

  日期：2012.4

  A simple, inexpensive, environmentally friendly, and highly efficient benzylation and allylation of 1,3-dicarbonyl compounds with sulfonamides in the presence of Yb(OTf)(3) is described. Yb(OTf)(3) was proved to be a good catalyst for the cleavage of sp(3) carbon-nitrogen bond. Various 1,3-dicarbonyl compounds can couple with a broad range of tosyl-activated benzylic and allylic amines to give diversely functionalized products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.
• Synthesis and structure of an air-stable bis(isopropylcyclopentadienyl) zirconium perfluorooctanesulfonate and its catalyzed benzylation of 1,3-dicarbonyl derivatives with alcohols
  作者：Xiaohong Zhang、Renhua Qiu、Congcong Zhou、Jingxing Yu、Ningbo Li、Shuangfeng Yin、Xinhua Xu

  DOI：10.1016/j.tet.2014.12.101

  日期：2015.2

  An air-stable uninuclear complex of bis(isopropylcyclopentadienyl) zirconium perfluorooctane sulfonate (1a center dot H2O center dot 3THF) was successfully synthesized by the reaction of (i-PrCp)(2)ZrCl2 with C17SO3Ag. The compound 1a center dot H2O center dot 3THF was characterized by different techniques (such as X-ray single crystal diffraction, TG-DSC, conductivity measurement and acid strength) and found to have the similar nature of water tolerance, air-stability, thermally-stability and strong Lewis-acidity with that of our previously reported binuclear and uninuclear zirconocenes perfluorooctanesulfonate. This novel complex was confirmed to be an effective catalyst with good recyclability and reusability for the direct benzylation of 1,3-dicarbonyl derivatives using alcohols as alkylating agents. Various 1,3-dicarbonyl and alcohols derivatives can participate in the reaction, affording the corresponding monobenzylated products in competitive yields as compared to its counterparts, such as Cp2Zr(OSO17)(2)center dot 3H(2)O center dot THF and the traditional Lewis-acid catalysts. (C) 2015 Elsevier Ltd. All rights reserved.
• Fosse, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1907, vol. 145, p. 1291
  作者：Fosse

  DOI：——

  日期：——